The UCSF Pharmacogenetics of Membrane Transporters (PMT) Project is sponsored by the National Institutes of Health's National Institute of General Medical Sciences (grant U01 GM61390). The Project is part of the Pharmacogenetics Research Network and Knowledgebase. Information about the entire Network can be found at NIH Pharmacogenomics Research Network. Pharmacogenetics is the study of the genetic basis for variation in response to drugs. Membrane transporters play a major role in drug response in two ways. First, many drugs work by affecting function of transporters. Second, transporters determine the level of drugs within the body by mediating drug absorption, distribution and elimination. Transporters are also determinants of drug resistance. The goal of the UCSF PMT Project is to understand the genetic basis for variation in response for drugs that interact with membrane transporters. Support for the bioinformatics activities of the PMT project also comes from the NIH/NIGMS Biomedical Technology Research Center (grant P41 GM103311).
The PMT project began in 2000. Our current research focuses on two major superfamilies, the Solute Carrier Superfamily (SLC) and the ATP Binding Cassette (ABC) Superfamily. Our SNP discovery studies include coding and non-coding regions of transporter genes. These studies focus on identifying genetic variants in membrane transporters in ethnically diverse populations. A fairly complete list of SLC and ABC transporters in the human genome is available. If you are a researcher in the Pharmacogenetics Research Network, please let us know if you are studying drug response pathways in these two superfamilies, as it may be possible to place the relevant transporters involved in these pathways in our high priority group for SNP discovery.
This database provides information on genetic variants (including single nucleotide polymorphisms (SNPs) and insertions/deletions) in membrane transporter genes that have been discovered by the PMT project. Positions of the SNPs and allele frequencies in major racial and ethnic populations are provided. All variants are mapped to the gene structure, and variants that alter the protein sequences of the transporters are mapped to the secondary structure of the transporters. Links to information on each transporter on NCBI databases are provided.