UCSF Pharmacogenetics of Membrane Transporters
Experiment View
NM_033125
XM_005267183
XM_005267184
XM_005267185
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Transcript:NM_033125 [Chr.6(-): 110745890-110797844 GRCh37]
Id:SLC22A16-P SEQ
Position:Chr.6(+): 110797694-110798444 GRCh37
Chr.6(+): 110904387-110905137 NCBI36
Sequence:
CGCGTGGCGCCGCGGGGCCCCTCCCCCATACCTGCCGAAGTGCCCCACGTGGTCATAAATCCCCTCGAAGTGGCGGGACC
CCAT
GGTGCGGCCGTGCACTGGGCGCCGAGTTAGCCGAGCTCCGGGGGCTGCGGGTAGCGCGCCCCGCCCCGAACCTCCC
CGCCCGGCCTCCTGCTCTCCCCGCGCGTCCCAGTGCTCGGGACCAGCGCGACGCTGTATTCTGTTCCTCCCTCCGTCGCT
TGGCCCCTCGGTCCCCCCAAGTATCTTCGGCTTTTTTCCTGCCGCCTCGGCCTCCTTCCCGGCGCGCTGTGGTCCCGGCG
CCCGCAGTCGCATGGTGCCCTCGCCCCCAGCCCCGCCGCTCTCCCACCCGCCCCGCCGCCCACCCTGGCTCTTGGCACCA
TGTCTGCGGGGTCGCCACGCTCGAGGGAAGCCCCGACGCCTGGGAAAAGTTGTCGCTGAGAGAGAGCCCAGGGTGGGAAT
GCAAGGGCTAGGCTCGGTCCGGGGGCCGCAAGAATATATAGCCTTCAGCATGACGCCCCTCAGAAACATGGCTCTCAAAC
TTTAATGCCTAAGAATCTACTGCAGAACTTGGTTTAAAAGGTACATTTAAGGCCGGGCGCACTTGCTCACGCCTGTAATC
CCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACCTGAGGTCGGGAGTTCAAGACTAGCCTGACCAACATGGAGAAACCC
CGTCTCCACTAAAAATACAAAATTAGCCGGG
Color Legend: SNP  UTR  CODING
Sample Sets: PMT-272
Assays: SLC22A16-P
PMT impact: P - Public  D - Discovered  E - Exclusive  (dbSNP build 142)
Array availability: I - found on Illumina Human1M-Duo BeadChip (2011-04-21)  A - found on Affymetrix Genome-Wide SNP Array 6.0 (2011-06-21)  
FeaturePMT IDdbSNP/ PubMedArray AvailabilityGenomic PositionTranscript PositionCoding PositionNucleotide ChangeStrandAmino Acid PositionAmino Acid ChangeStatisticsAA FreqCA FreqAS FreqME FreqSample Set
Exon 1: 5UTR
Promoter
4279
PDE
110797821 GRCh37
110904514 NCBI36
24-44
GCGCCGAGTTAGCCGAGCTCCGGGG G → A CTGCGGGTAGCGCGCCCCGCCCCGA
+ 
 
n=
G/G=
G/A=
A/A=
A=
130
59
6
0
0.046
132
64
2
0
0.015
132
60
6
0
0.045
132
60
6
0
0.045
PMT-272
Exon 1: 5UTR
Promoter
4280
PDE
110797826 GRCh37
110904519 NCBI36
19-49

G → A, T
GAGTTAGCCGAGCTCCGGGGGCTGC G → A GGTAGCGCGCCCCGCCCCGAACCTC
GAGTTAGCCGAGCTCCGGGGGCTGC G → T GGTAGCGCGCCCCGCCCCGAACCTC
+ 

 
 
 
n=
G/G=
G/A=
A/A=
G/T=
T/T=
A/T=
A=
T=
130
51
0
0
13
1
0
0.000
0.115
132
64
1
0
1
0
0
0.008
0.008
132
66
0
0
0
0
0
0.000
0.000
132
64
1
0
1
0
0
0.008
0.008
PMT-272
Promoter
4281
PDE
110797896 GRCh37
110904589 NCBI36
-52-119
TCCCCGCGCGTCCCAGTGCTCGGGA C → T CAGCGCGACGCTGTATTCTGTTCCT
+ 
 
n=
C/C=
C/T=
T/T=
T=
130
61
4
0
0.031
132
66
0
0
0.000
132
66
0
0
0.000
132
66
0
0
0.000
PMT-272
Promoter
4282
PDE
110797905 GRCh37
110904598 NCBI36
-61-128
GTCCCAGTGCTCGGGACCAGCGCGA C → G GCTGTATTCTGTTCCTCCCTCCGTC
+ 
 
n=
C/C=
C/G=
G/G=
G=
130
19
35
11
0.438
132
50
15
1
0.129
132
32
30
4
0.288
132
49
17
0
0.129
PMT-272
Promoter
4283
PDE
110797946 GRCh37
110904639 NCBI36
-102-169
TCCCTCCGTCGCTTGGCCCCTCGGT C → - CCCCCAAGTATCTTCGGCTTTTTTC
+ 
 
n=
C/C=
C/-=
-/-=
-=
130
20
35
10
0.423
132
50
15
1
0.129
132
33
29
4
0.280
132
49
17
0
0.129
PMT-272
Promoter
4284
PDE
110797952 GRCh37
110904645 NCBI36
-108-175
CGTCGCTTGGCCCCTCGGTCCCCCC A → T AGTATCTTCGGCTTTTTTCCTGCCG
+ 
 
n=
A/A=
A/T=
T/T=
T=
130
52
13
0
0.100
132
52
14
0
0.106
132
39
24
3
0.227
132
57
9
0
0.068
PMT-272
Promoter
4285
PDE
110797998 GRCh37
110904691 NCBI36
-154-221
TGCCGCCTCGGCCTCCTTCCCGGCG C → CGC GCTGTGGTCCCGGCGCCCGCAGTCG
+ 
 
n=
C/C=
C/CGC=
CGC/CGC=
CGC=
130
28
33
4
0.315
132
51
14
1
0.121
132
33
29
4
0.280
132
50
16
0
0.121
PMT-272
Promoter
4286
PDE
110798019 GRCh37
110904712 NCBI36
-175-242
GGCGCGCTGTGGTCCCGGCGCCCGC A → G GTCGCATGGTGCCCTCGCCCCCAGC
+ 
 
n=
A/A=
A/G=
G/G=
G=
130
20
35
10
0.423
132
50
15
1
0.129
132
32
30
4
0.288
132
49
17
0
0.129
PMT-272
Promoter
4287
PDE
110798045 GRCh37
110904738 NCBI36
-201-268
GTCGCATGGTGCCCTCGCCCCCAGC C → G CCGCCGCTCTCCCACCCGCCCCGCC
+ 
 
n=
C/C=
C/G=
G/G=
G=
128
18
33
13
0.461
132
50
15
1
0.129
132
32
30
4
0.288
132
49
17
0
0.129
PMT-272
 
4288
PDE
110798118 GRCh37
110904811 NCBI36
-274-341
ATGTCTGCGGGGTCGCCACGCTCGA G → A GGAAGCCCCGACGCCTGGGAAAAGT
+ 
 
n=
G/G=
G/A=
A/A=
A=
128
49
15
0
0.117
132
65
1
0
0.008
132
66
0
0
0.000
132
65
1
0
0.008
PMT-272
 
4289
PDE
110798217 GRCh37
110904910 NCBI36
-373-440
CCGGGGGCCGCAAGAATATATAGCC T → A TCAGCATGACGCCCCTCAGAAACAT
+ 
 
n=
T/T=
T/A=
A/A=
A=
128
61
3
0
0.023
132
51
13
2
0.129
132
39
22
5
0.242
132
54
12
0
0.091
PMT-272

Transmembrane prediction:

Non-synonymous amino acid changes shown in red, indels (insertions and deletions) in blue, and synonymous changes in green. Exon(s) indicated by black outlines.