UCSF Pharmacogenetics of Membrane Transporters
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Common Name:MRP3
HGNC Symbol:ABCC3
HGNC Description:ATP-binding cassette, sub-family C (CFTR/MRP), member 3
HGNC ID:54
Chromosome:Chr.17(+): 46067227-46124062
Location:17q22
OMIM:604323
OMIM Phenotype:None
Accessions:AF009670, AF085690
Nucleotide RefSeq:NM_003786
Protein RefSeq:NP_003777
Entrez:8714
Isoforms:2
Evidence:Substrate In Vitro Evidence: Epipodophyllotoxins Methotraxate - Drug resistence of MDCKII transfected with ABCC3. Kool M, et al. PNAS. 1999; 96: 6914-9. Vincristine Etoposide - Drug resistance of HEK-293 transfected with ABCC3. Zeng H, et al. Cancer Research. 1999; 59: 5964-5967. Estradiol 17-[pic]-D-glucuronide KM = 25 uM DNP-SG KM = 5.7 uM LTC4 KM = 5.3 uM - Membrane vesicles. Zeng H, et al. Cancer Research. 2000; 60: 4779-84. Glycocholate Glycochenodeoxycholate Taurodeoxycholate Taurochenodeoxycholate - Inside-out vesicles measuring estradiol 17-[pic]-D-glucuronide transport. Bodo A. JBC. 2003; 278: 23529-37. Glucuronides Substrate In Vivo Evidence: Gemfibrozil - Mrp2 deficient rats. Kim MS, et al. Xenobiotica. 2003 Oct;33(10):1027-42. Tissue Distribution Evidence: Adrenal gland >> Liver 1. TaqMan RT-PCR. Langmann T, et al. Clinical Chemistry. 2003; 49: 230-8. Adrenal gland, Kidney, Colon, Pancreas, Gallbladder, Liver 1. Western Blot and Immunohistochemistry. Scheffer GL, et al. Lab. Invest. 2002; 82:193-201.
Tissues:Adrenal gland, Kidney, Colon, Pancreas, Gallbladder, Liver
Type:protein coding
Sets:II,IV
PharmGKB ID:PA376
HPRD ID:06826
Substrates:Epipodophyllotoxins, Methotraxate, Vincristine, Etoposide, Estradiol 17-Beta-D-glucuronide, DNP-SG, LTC4, Glycocholate, Glycochenodeoxycholate, Taurodeoxycholate, Taurochenodeoxycholate, Glucuronides, Gemfibrozil
Trivial Names:MLP2, MRP3, ABC31, MOAT-D, cMOAT2, EST90757, DKFZp686E22157
Transcripts:NM_003786 [Chr.17(+): 46067217-46124062]
NM_001144070 [Chr.17(+): 46067217-46100287]
View on UCSC Genome Browser or Ensembl Genome Browser
ABCC3 RESEQUENCING
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Study Name:ABCC3 RESEQUENCING
Experiments:
SNP impact: P - Public  D - Discovered  E - Exclusive  (dbSNP build 130)
SNP array availability: I - found on Illumina Human1M-Duo BeadChip  A - found on Affymetrix Genome-Wide SNP Array 6.0  
FeaturePMT SNP IDdbSNP/ PubMedSNP Array AvailabilityGenomic PositionTranscript PositionCoding PositionNucleotide ChangeStrand, '+' or '-'Amino Acid PositionAmino Acid ChangeStatisticsAA FreqCA FreqAS FreqME FreqPA FreqSample Set
Promoter
2995
PDE
rs9895420
 46067037-180-260
GTATTTAGAGAGACATCCCCCTGGC T → A TGGCCCAGGGGCCGCTCGCAGGGGC
+ 
 
n=
T/T=
T/A=
A/A=
A=
80
25
11
4
0.237
100
41
8
1
0.100
98
46
3
0
0.031
56
23
5
0
0.089
n/a
0.000
PMT-272
Promoter
2996
PDE
rs4793665
6 pubs		 46067086-131-211
GCTGTCGCCGTGCCAAGGGCCCCCC C → T ACCTCTGCCCCAAAGTCCCTCCCAG
+ 
 
n=
C/C=
C/T=
T/T=
T=
80
8
21
11
0.537
100
11
22
17
0.560
98
0
7
42
0.929
56
6
14
8
0.536
n/a
0.000
PMT-272
Exon: Coding
4414
PDE
rs11568609
1 pub		 4606732811232
GCCCTGTGCGGTTCCGGGGAGCTCG G → A CTCCAAGTTCTGGGTAAGGCGCGGG
+11
Gly → Asp
n=
G/G=
G/A=
A/A=
A=
160
80
0
0
0.000
160
80
0
0
0.000
120
59
1
0
0.008
100
50
0
0
0.000
12
6
0
0
0.000
Set-II
Exon: Coding
4415
PDE
rs34926034
1 pub		 46088348282202
TTGTCGTGGCTACATCATCCTCTCC C → T ACCTGTCCAAGCTCAAGATGGTCAG
+68
His → Tyr
n=
C/C=
C/T=
T/T=
T=
160
80
0
0
0.000
158
78
1
0
0.006
120
60
0
0
0.000
100
50
0
0
0.000
10
5
0
0
0.000
Set-II
 
4416
PDE
rs34495663
 46088436  
GGGATTCTGCTTTTATTTTTTAATT T → A AATTAAATTAATTAATTAATTAATT
+ 
 
n=
T/T=
T/A=
A/A=
A=
160
80
0
0
0.000
158
77
1
1
0.019
120
60
0
0
0.000
100
50
0
0
0.000
10
5
0
0
0.000
Set-II
 
4417
PDE
rs35084367
 46088443  
TGCTTTTATTTTTTAATTTAATTAA A → - TTAATTAATTAATTAATTTAGAGAC
+ 
 
n=
A/A=
A/-=
-/-=
-=
160
80
0
0
0.000
158
79
0
0
0.000
120
59
1
0
0.008
100
50
0
0
0.000
10
5
0
0
0.000
Set-II
 
4418
PDE
rs36113702
 46088471  
AATTAATTAATTAATTTAGAGACAG A → - GTCTCACTCTGTCGCCCAGGCTGGA
+ 
 
n=
A/A=
A/-=
-/-=
-=
160
80
0
0
0.000
158
79
0
0
0.000
120
59
1
0
0.008
100
50
0
0
0.000
10
5
0
0
0.000
Set-II
 
4419
PDE
rs35850297
 46088472  
ATTAATTAATTAATTTAGAGACAGA G → - TCTCACTCTGTCGCCCAGGCTGGAG
+ 
 
n=
G/G=
G/-=
-/-=
-=
160
80
0
0
0.000
158
79
0
0
0.000
120
59
1
0
0.008
100
50
0
0
0.000
10
5
0
0
0.000
Set-II
 
4420
PDE
rs12103933
 46088520  
GAGTGCAGTGGCATGATCTTGGCTC A → G CTGCAACCTCTGCCTTCTGGGTTCA
+ 
 
n=
A/A=
A/G=
G/G=
G=
160
68
10
2
0.087
158
79
0
0
0.000
116
58
0
0
0.000
100
49
1
0
0.010
8
4
0
0
0.000
Set-II
Exon: Coding
4421
PDE
rs35777968
1 pub		 46089135376296
TCCTTCCATGGCCTGGTCCATGGCC G → A GGCCCCTGCCCCTGTTTTCTTTGTC
+99
Arg → Gln
n=
G/G=
G/A=
A/A=
A=
160
77
3
0
0.019
160
80
0
0
0.000
120
60
0
0
0.000
100
50
0
0
0.000
12
6
0
0
0.000
Set-II
Exon: Coding
4422
PDE
rs35206567
 46089172413333
CTGTTTTCTTTGTCACCCCCTTGGT G → A GTGGGGGTCACCATGGTCAGTGTGG
+111
Val = Val
n=
G/G=
G/A=
A/A=
A=
160
79
1
0
0.006
160
80
0
0
0.000
120
60
0
0
0.000
100
50
0
0
0.000
12
6
0
0
0.000
Set-II
 
4423
PDE
rs2301836
I46089353  
GCCATGTGGGATGGGGAGAAATGGA G → A GCAGGTCCAGATGTGTGTGTTCTGC
+ 
 
n=
G/G=
G/A=
A/A=
A=
160
72
7
1
0.056
160
74
6
0
0.037
120
49
10
1
0.100
100
45
5
0
0.050
10
3
1
1
0.300
Set-II
Exon: Coding
4424
PDE
rs34924566
 46089491514434
CTCATTATCTTCTGGTTCCTGTGTG T → C GGTCTGCGCCATCGTCCCATTCCGC
+145
Val → Ala
n=
T/T=
T/C=
C/C=
C=
160
79
1
0
0.006
160
80
0
0
0.000
120
60
0
0
0.000
100
50
0
0
0.000
10
5
0
0
0.000
Set-II
 
4425
PDE
rs11568585
 46090391  
AAGGGACTCCGCAGGGCAGGGGCTG C → T AGGCCCAGGCTTTTCCAGTGCTTCT
+ 
 
n=
C/C=
C/T=
T/T=
T=
158
79
0
0
0.000
158
79
0
0
0.000
120
60
0
0
0.000
100
50
0
0
0.000
10
4
1
0
0.100
Set-II
 
4426
PDE
rs11568586
I46090585  
TCGACCCTGTGAGTTTCCCATGGAG G → A GTGCGGGGGCTCCACAGCTGAGTCC
+ 
 
n=
G/G=
G/A=
A/A=
A=
158
75
4
0
0.025
158
78
1
0
0.006
120
60
0
0
0.000
100
50
0
0
0.000
10
5
0
0
0.000
Set-II
 
4427
PDE
rs739923
IA46090773  
GGTGGTGGGCACTCCTGATTCCCCC G → A TCCTATTCTCTCGCCTTCTAGAACC
+ 
 
n=
G/G=
G/A=
A/A=
A=
160
47
29
4
0.231
160
45
29
6
0.256
120
33
22
5
0.267
100
21
25
4
0.330
12
3
3
0
0.250
Set-II
Exon: Coding
4428
PDE
rs35669870
 46090836734654
CCAGCGCTGGCTTTCTCTCCCGCCT G → A TTTTTCTGGTGGTTCACAAAGTGAG
+218
Leu = Leu
n=
G/G=
G/A=
A/A=
A=
160
78
2
0
0.013
160
80
0
0
0.000
120
60
0
0
0.000
100
50
0
0
0.000
12
6
0
0
0.000
Set-II
 
4429
PDE
rs35319009
 46091560  
GCTCCAGGCTGCTAAACCCTGACCC T → G CTGCGGGGCTGCCTGCCGGGCTTCA
+ 
 
n=
T/T=
T/G=
G/G=
G=
160
79
1
0
0.006
158
79
0
0
0.000
120
60
0
0
0.000
100
50
0
0
0.000
10
5
0
0
0.000
Set-II
 
4430
PDE
rs34576333
 46091747  
CGGCACGGTGAGGCCCTCCCCTTGC C → G CCAACACCCAGCCCCTTCGCTTACC
+ 
 
n=
C/C=
C/G=
G/G=
G=
160
79
1
0
0.006
158
79
0
0
0.000
120
60
0
0
0.000
100
50
0
0
0.000
10
5
0
0
0.000
Set-II
 
4431
PDE
rs2301837
I46093265  
CTGTCCCCATTCCTAACCCACTGCT C → T CTTCCTCCCTGGACCAGACACAAGG
+ 
 
n=
C/C=
C/T=
T/T=
T=
160
69
11
0
0.069
160
69
11
0
0.069
120
51
8
1
0.083
100
42
8
0
0.080
10
5
0
0
0.000
Set-II
Exon: Coding
4432
PDE
rs45617731
I460934171021941
ACCTTCGGCTCCAGCTTCCTCATCA G → T TGCCTGCTTCAAGCTTATCCAGGAC
+314
Ser → Ile
n=
G/G=
G/T=
T/T=
T=
160
79
1
0
0.006
160
80
0
0
0.000
120
60
0
0
0.000
100
50
0
0
0.000
10
5
0
0
0.000
Set-II
 
4433
PDE
rs11568581
 46093490  
AGCTGCTCAGGTCTCTCCACACTCC G → A GCTCACTATAGCCCTGCCCTGGGCA
+ 
 
n=
G/G=
G/A=
A/A=
A=
160
79
1
0
0.006
160
69
10
1
0.075
120
60
0
0
0.000
100
49
1
0
0.010
10
5
0
0
0.000
Set-II
Exon: Coding
4434
PDE
rs11568604
I4609605910971017
CCCACAGCATCCTGATCAGGTTTAT C → T TCCAACCCCATGGCCCCCTCCTGGT
+339
Ile = Ile
n=
C/C=
C/T=
T/T=
T=
160
80
0
0
0.000
160
80
0
0
0.000
120
57
3
0
0.025
100
50
0
0
0.000
12
6
0
0
0.000
Set-II
Exon: Coding
4435
PDE
rs11568605
2 pubs		I4609607911171037
TTTATCTCCAACCCCATGGCCCCCT C → T CTGGTGGGGCTTCCTGGTGGCTGGG
+346
Ser → Phe
n=
C/C=
C/T=
T/T=
T=
160
79
1
0
0.006
160
76
4
0
0.025
120
60
0
0
0.000
100
50
0
0
0.000
12
6
0
0
0.000
Set-II
 
4436
PDE
rs11568606
 46096275  
GGCCCTGGGCAGCTTGCAAGAGGCT C → T GCAGCCAAGTCCACCCACTACTGTC
+ 
 
n=
C/C=
C/T=
T/T=
T=
160
79
1
0
0.006
160
80
0
0
0.000
120
60
0
0
0.000
100
50
0
0
0.000
12
6
0
0
0.000
Set-II
Exon: Coding
4437
PDE
rs34346931
 4609635613031223
GTCAAACGTGCGTCCACTGTGGGGG A → G AATTGTCAACCTCATGTCAGTGGAT
+408
Glu → Gly
n=
A/A=
A/G=
G/G=
G=
160
79
1
0
0.006
160
80
0
0
0.000
120
60
0
0
0.000
100
50
0
0
0.000
12
6
0
0
0.000
Set-II
Exon: Coding
4438
PDE
rs11568602
 4609995215501470
AATTGAAGGACTCGCGCATCAAGCT G → C ATGAGTGAGATCCTGAACGGCATCA
+490
Leu = Leu
n=
G/G=
G/C=
C/C=
C=
160
76
4
0
0.025
160
80
0
0
0.000
120
60
0
0
0.000
100
50
0
0
0.000
12
6
0
0
0.000
Set-II
Exon: Coding
4439
PDE
rs11568601
 4610003416321552
CTTCCTGAAGCAGGTGGAGGGCATC A → C GGCAGGGTGAGCTCCAGCTGCTGCG
+518
Arg = Arg
n=
A/A=
A/C=
C/C=
C=
160
79
1
0
0.006
160
75
5
0
0.031
120
60
0
0
0.000
100
50
0
0
0.000
12
6
0
0
0.000
Set-II
Exon: Coding
4440
PDE
rs11568603
I4610006316611581
AGGGTGAGCTCCAGCTGCTGCGCAC G → T GCGGCCTACCTCCACACCACAACCA
+527
Thr = Thr
n=
G/G=
G/T=
T/T=
T=
160
79
1
0
0.006
160
80
0
0
0.000
120
60
0
0
0.000
100
50
0
0
0.000
12
6
0
0
0.000
Set-II
 
4441
PDE
rs11568610
 46100374  
TTAATCAGCAACCTGACTCAGGTAA C → A CCTGGGTAGGGCTGGGGGCTCTACT
+ 
 
n=
C/C=
C/A=
A/A=
A=
160
80
0
0
0.000
152
76
0
0
0.000
112
56
0
0
0.000
98
48
1
0
0.010
10
5
0
0
0.000
Set-II
 
4442
PDE
rs11568607
I46100786  
CTCTAGGGCTGACTCACATCCTCCC G → A TAGGCCAGTGTGTCTCTGAAACGGA
+ 
 
n=
G/G=
G/A=
A/A=
A=
160
71
9
0
0.056
160
80
0
0
0.000
120
60
0
0
0.000
100
49
1
0
0.010
10
5
0
0
0.000
Set-II
Exon: Coding
4443
PDE
rs11568608
1 pub		I4610082719001820
CTGAAACGGATCCAGCAATTCCTGA G → A CCAAGAGGAACTTGACCCCCAGAGT
+607
Ser → Asn
n=
G/G=
G/A=
A/A=
A=
160
75
5
0
0.031
160
80
0
0
0.000
120
60
0
0
0.000
100
49
1
0
0.010
10
5
0
0
0.000
Set-II
 
4444
PDE
rs11568600
 46101191  
CATCCCTTGAGCTCCCTCCCTGACC C → G TGCCCACCTTGGTCCTCTCAGGCTA
+ 
 
n=
C/C=
C/G=
G/G=
G=
160
80
0
0
0.000
160
79
1
0
0.006
118
59
0
0
0.000
100
50
0
0
0.000
12
6
0
0
0.000
Set-II
Exon: Coding
4445
PDE
rs11568599
 4610126820061926
TCACCTGGGCCCAGGACCTGCCCCC C → A ACTCTGCACAGGTACCAGCTTCTCC
+642
Pro = Pro
n=
C/C=
C/A=
A/A=
A=
160
80
0
0
0.000
160
79
1
0
0.006
118
59
0
0
0.000
100
49
1
0
0.010
12
6
0
0
0.000
Set-II
Exon: Coding
4446
PDE
rs11568584
I4610180022332153
CTTTTCGGCAAAGCCCTGAACCCCA A → T GCGCTACCAGCAGACTCTGGAGGCC
+718
Lys → Met
n=
A/A=
A/T=
T/T=
T=
154
77
0
0
0.000
160
80
0
0
0.000
120
60
0
0
0.000
100
49
1
0
0.010
12
6
0
0
0.000
Set-II
 
4447
PDE
rs4794176
 46101922  
TCCTCTTCCATCCCTAAGAGGCTAG G → C GCATAGAGCTGCCCACCTCAACCCA
+ 
 
n=
G/G=
G/C=
C/C=
C=
154
0
14
63
0.909
160
1
23
56
0.844
120
6
27
27
0.675
100
1
12
37
0.860
12
0
2
4
0.833
Set-II
 
4448
PDE
rs34925102
 46105281  
CAAATAACAGTGGACAGGCCGTTGT C → T TCCCTGTGCCTGTCTGACCCCATTT
+ 
 
n=
C/C=
C/T=
T/T=
T=
160
80
0
0
0.000
160
80
0
0
0.000
120
60
0
0
0.000
100
49
1
0
0.010
12
6
0
0
0.000
Set-II
 
4449
PDE
rs35899561
 46105318  
GTCTGACCCCATTTTTCCCACCCCC C → CC GCCTCCCTCCAGGGCATTAACCTGT
+ 
 
n=
C/C=
C/CC=
CC/CC=
CC=
160
80
0
0
0.000
160
80
0
0
0.000
120
59
1
0
0.008
100
50
0
0
0.000
12
6
0
0
0.000
Set-II
Exon: Coding
4450
PDE
rs34291385
1 pub		 4610538223732293
GCAGCGGGTCAGTCTGGCTCGAGCT G → C TTTACAGTGATGCCGATATTTTCTT
+765
Val → Leu
n=
G/G=
G/C=
C/C=
C=
160
75
5
0
0.031
160
80
0
0
0.000
120
60
0
0
0.000
100
49
1
0
0.010
12
6
0
0
0.000
Set-II
Exon: Coding
4451
PDE
rs34696691
 4610539723882308
GGCTCGAGCTGTTTACAGTGATGCC G → A ATATTTTCTTGCTGGATGACCCACT
+770
Asp → Asn
n=
G/G=
G/A=
A/A=
A=
160
80
0
0
0.000
160
80
0
0
0.000
120
60
0
0
0.000
100
49
1
0
0.010
12
6
0
0
0.000
Set-II
 
4452
PDE
rs35450564
 46105545  
GGGGGCTAAGGTGAGATCTGAGGCC C → T GAAGAGAGAGCTGGTGAGAGGCTGA
+ 
 
n=
C/C=
C/T=
T/T=
T=
160
79
1
0
0.006
160
80
0
0
0.000
120
60
0
0
0.000
100
50
0
0
0.000
12
6
0
0
0.000
Set-II
 
4453
PDE
rs2240801
I46105801  
CCAGGGGTGTGCTGGAGGGTGGTAG G → A GGTGAGAGCCTGCTGCCTTCTCCCC
+ 
 
n=
G/G=
G/A=
A/A=
A=
160
80
0
0
0.000
160
80
0
0
0.000
120
57
3
0
0.025
98
46
3
0
0.031
12
6
0
0
0.000
Set-II
Exon: Coding
4454
PDE
rs34675700
 4610584525062426
TCTCCCCAGACGCGAGTGCTGGTGA C → T GCACGGCATTAGCTTCCTGCCCCAG
+809
Thr → Met
n=
C/C=
C/T=
T/T=
T=
160
80
0
0
0.000
160
79
1
0
0.006
120
60
0
0
0.000
98
49
0
0
0.000
12
6
0
0
0.000
Set-II
 
4455
PDE
rs4148415
I46107599  
AGTCTTTCTTGTTGCCCTTTCAATC C → T CCCTCATTTTATTTTCATGCTTGTC
+ 
 
n=
C/C=
C/T=
T/T=
T=
160
65
14
1
0.100
160
29
40
11
0.388
120
20
36
4
0.367
100
20
24
6
0.360
10
5
0
0
0.000
Set-II
Exon: Coding
4456
PDE
rs35892518
 4610778227402660
ATTGAAGACACACTCAGCAACCACA C → T GGATCTGACAGACAATGATCCAGTC
+887
Thr → Met
n=
C/C=
C/T=
T/T=
T=
160
79
1
0
0.006
160
80
0
0
0.000
120
60
0
0
0.000
100
50
0
0
0.000
10
5
0
0
0.000
Set-II
 
4457
PDE
rs2072365
I46107865  
AGTTCCTGAGAGCTCCCAGCCCTCC C → T GGAGGCTGTATCAGGCCTCCCCAGG
+ 
 
n=
C/C=
C/T=
T/T=
T=
160
65
14
1
0.100
160
29
40
11
0.388
120
20
36
4
0.367
100
20
23
7
0.370
10
5
0
0
0.000
Set-II
 
4458
PDE
rs2072366
 46107889  
CCGGAGGCTGTATCAGGCCTCCCCA G → A GCCCTGCCAGATGGGGTGCAGGTTT
+ 
 
n=
G/G=
G/A=
A/A=
A=
160
22
28
30
0.550
160
10
41
29
0.619
120
5
25
30
0.708
100
6
27
17
0.610
10
0
1
4
0.900
Set-II
Exon: Coding
4459
PDE
rs34590740
 4610799427982718
GCCTGACCAGCTGCCTCCACAGACA G → A CTGAGTGCCCTGTCCTCAGATGGGG
+906
Gln = Gln
n=
G/G=
G/A=
A/A=
A=
160
80
0
0
0.000
160
79
1
0
0.006
118
59
0
0
0.000
100
49
1
0
0.010
12
6
0
0
0.000
Set-II
Exon: Coding
4460
PDE
rs35458882
 4610801828222742
AGCTGAGTGCCCTGTCCTCAGATGG G → T GAGGGACAGGGTCGGCCTGTACCCC
+914
Gly = Gly
n=
G/G=
G/T=
T/T=
T=
160
80
0
0
0.000
160
79
1
0
0.006
118
59
0
0
0.000
100
50
0
0
0.000
12
6
0
0
0.000
Set-II
Exon: Coding
4461
PDE
rs35999272
1 pub		 4610803428382758
CTCAGATGGGGAGGGACAGGGTCGG C → T CTGTACCCCGGAGGCACCTGGGTCC
+920
Pro → Ser
n=
C/C=
C/T=
T/T=
T=
160
63
16
1
0.113
160
80
0
0
0.000
118
59
0
0
0.000
100
50
0
0
0.000
12
6
0
0
0.000
Set-II
Exon: Coding
4462
PDE
rs34502058
1 pub		 4610804428482768
GAGGGACAGGGTCGGCCTGTACCCC G → A GAGGCACCTGGGTCCATCAGAGAAG
+923
Arg → Gln
n=
G/G=
G/A=
A/A=
A=
160
79
1
0
0.006
160
78
2
0
0.013
118
59
0
0
0.000
100
50
0
0
0.000
12
6
0
0
0.000
Set-II
Exon: Coding
4463
PDE
rs4148416
I4610842231193039
AGAACAACACTTCCCTGAGGCTGGG C → T GTCTATGCTGCTTTAGGAATTCTGC
+1013
Gly = Gly
n=
C/C=
C/T=
T/T=
T=
160
53
26
1
0.175
158
65
14
0
0.089
120
44
13
3
0.158
98
39
10
0
0.102
12
5
1
0
0.083
Set-II
Exon: Coding
4464
PDE
rs11568587
I4610843431313051
CCCTGAGGCTGGGCGTCTATGCTGC T → C TTAGGAATTCTGCAAGGTGAGCTTG
+1017
Ala = Ala
n=
T/T=
T/C=
C/C=
C=
160
80
0
0
0.000
158
79
0
0
0.000
120
60
0
0
0.000
98
48
1
0
0.010
12
6
0
0
0.000
Set-II
 
4465
PDE
rs8077268
 46108521  
CTCTGGGCTGCCAGGCCCCCCAAAC C → T GTGCCCTTGCATCCAAGCCTCCCTA
+ 
 
n=
C/C=
C/T=
T/T=
T=
160
69
11
0
0.069
158
69
9
1
0.070
120
59
1
0
0.008
98
42
7
0
0.071
12
5
1
0
0.083
Set-II
 
4466
PDE
rs11568596
 46108596  
CTGATTCTGCCCCTTTGTGCCCGCT C → T ACTAGTCCAGGTGAGCCAGCGCCCT
+ 
 
n=
C/C=
C/T=
T/T=
T=
160
80
0
0
0.000
160
79
1
0
0.006
120
60
0
0
0.000
98
49
0
0
0.000
12
6
0
0
0.000
Set-II
 
4467
PDE
rs11568595
I46108975  
TGTGGGGTGGGCGTGATTCCAGTGT G → A GGCGTGGTGTTATTGGGGCGGGGCA
+ 
 
n=
G/G=
G/A=
A/A=
A=
160
71
9
0
0.056
160
80
0
0
0.000
120
60
0
0
0.000
98
49
0
0
0.000
12
6
0
0
0.000
Set-II
Exon: Coding
4907
PDE
rs34620384
 4611022135763496
TGCCAGTGTCATCCGGGCCTACAAC C → T GCAGCCGGGATTTTGAGATCATCAG
+1166
Arg → Cys
n=
C/C=
C/T=
T/T=
T=
160
79
1
0
0.006
160
80
0
0
0.000
118
59
0
0
0.000
100
50
0
0
0.000
12
6
0
0
0.000
Set-II
 
4468
PDE
rs967935
 46110387  
TGTTCAGGGTCCTTGTCCCTCCTTT C → T CCCTAAGCAGAAAACTGGCCCTGCC
+ 
 
n=
C/C=
C/T=
T/T=
T=
160
63
16
1
0.113
160
67
13
0
0.081
120
44
13
3
0.158
100
41
9
0
0.090
12
5
1
0
0.083
Set-II
 
4469
PDE
rs11568583
 46110449  
CCATTTCCTCCTCATCTGATCCCCC A → G TAGGTGGCTGAGCATCGGAGTGGAG
+ 
 
n=
A/A=
A/G=
G/G=
G=
160
80
0
0
0.000
160
80
0
0
0.000
120
56
4
0
0.033
100
50
0
0
0.000
12
6
0
0
0.000
Set-II
Exon: Coding
4470
PDE
rs11568582
I4611051637223642
TGGTGCTCTTTGCTGCACTATTTGC C → T GTCATCGGGAGGAGCAGCCTGAACC
+1214
Ala = Ala
n=
C/C=
C/T=
T/T=
T=
160
79
1
0
0.006
160
80
0
0
0.000
120
60
0
0
0.000
100
50
0
0
0.000
12
6
0
0
0.000
Set-II
 
4471
PDE
rs11568594
 46112096  
ACATGATCCAGGAGTCTGAACTCCT C → T CCAAAGCCATTACGGTGGGGAGGGG
+ 
 
n=
C/C=
C/T=
T/T=
T=
160
79
1
0
0.006
160
80
0
0
0.000
120
60
0
0
0.000
100
50
0
0
0.000
12
6
0
0
0.000
Set-II
Exon: Coding
4908
PDE
rs11568593
1 pub		 4611601839363856
CCGCCCTCCCGAAGGTTGGCCCCCA C → G GTGGGGAGGTGGAGTTCCGGAATTA
+1286
Arg → Gly
n=
C/C=
C/G=
G/G=
G=
160
79
1
0
0.006
160
80
0
0
0.000
120
60
0
0
0.000
100
50
0
0
0.000
12
6
0
0
0.000
Set-II
Exon: Coding
4909
PDE
rs11568591
4 pubs		IA4611605239703890
GTGGAGTTCCGGAATTATTCTGTGC G → A CTACCGGCCGGGCCTAGACCTGGTG
+1297
Arg → His
n=
G/G=
G/A=
A/A=
A=
160
79
1
0
0.006
160
76
4
0
0.025
120
60
0
0
0.000
100
47
3
0
0.030
12
6
0
0
0.000
Set-II
Exon: Coding
4910
PDE
rs2277624
1 pub		I4611610440223942
TGAGAGACCTGAGTCTGCATGTGCA C → T GGTGGCGAGAAGGTACGCGTGGGGT
+1314
His = His
n=
C/C=
C/T=
T/T=
T=
160
42
32
6
0.275
160
44
31
5
0.256
120
30
27
3
0.275
100
29
16
5
0.260
12
4
2
0
0.167
Set-II
 
4911
PDE
rs11568592
 46116125  
TGCACGGTGGCGAGAAGGTACGCGT G → T GGGTAGGCGGGCCTGCGTGTGTGTT
+ 
 
n=
G/G=
G/T=
T/T=
T=
160
80
0
0
0.000
160
78
2
0
0.013
120
60
0
0
0.000
100
50
0
0
0.000
12
6
0
0
0.000
Set-II
Exon: Coding
4472
PDE
rs11568589
I4611636240884008
GCAAGTCTTCCATGACCCTTTGCCT G → A TTCCGCATCCTGGAGGCGGCAAAGG
+1336
Leu = Leu
n=
G/G=
G/A=
A/A=
A=
160
80
0
0
0.000
160
79
1
0
0.006
120
60
0
0
0.000
100
49
1
0
0.010
12
6
0
0
0.000
Set-II
Exon: Coding
4473
PDE
rs11568588
1 pub		I4611639641224042
CCTGGAGGCGGCAAAGGGTGAAATC C → T GCATTGATGGCCTCAATGTGGCAGA
+1348
Arg → Cys
n=
C/C=
C/T=
T/T=
T=
160
70
8
2
0.075
160
80
0
0
0.000
120
60
0
0
0.000
100
50
0
0
0.000
12
6
0
0
0.000
Set-II
Exon: Coding
4474
PDE
rs11568590
1 pub		I4611644841744094
ATCGGCCTCCATGACCTGCGCTCTC A → G GCTGACCATCATCCCGCAGGTAGGA
+1365
Gln → Arg
n=
A/A=
A/G=
G/G=
G=
160
78
2
0
0.013
160
80
0
0
0.000
120
60
0
0
0.000
100
50
0
0
0.000
12
6
0
0
0.000
Set-II
 
4475
PDE
rs11568598
 46117059  
AGCTGCCTCCCTCTGAGGCCACGTT G → C TATCCCCAGGACCCCATCCTGTTCT
+ 
 
n=
G/G=
G/C=
C/C=
C=
160
80
0
0
0.000
160
80
0
0
0.000
120
59
1
0
0.008
100
50
0
0
0.000
12
6
0
0
0.000
Set-II
Exon: Coding
4476
PDE
rs45461799
1 pub		I4611709642214141
CCCCATCCTGTTCTCGGGGACCCTG C → A GCATGAACCTGGACCCCTTCGGCAG
+1381
Arg → Ser
n=
C/C=
C/A=
A/A=
A=
160
80
0
0
0.000
160
80
0
0
0.000
120
60
0
0
0.000
100
48
2
0
0.020
12
6
0
0
0.000
Set-II
Exon: Coding
4477
PDE
rs1051640
IA4612348545894509
TCCTGGACAAAGGAGTAGTAGCTGA A → G TTTGATTCTCCAGCCAACCTCATTG
+1503
Glu = Glu
n=
A/A=
A/G=
G/G=
G=
160
80
0
0
0.000
160
78
2
0
0.013
120
60
0
0
0.000
100
50
0
0
0.000
12
6
0
0
0.000
Set-II

Transmembrane prediction:

Non-synonymous amino acid changes shown in red, indels (insertions and deletions) in blue, and synonymous changes in green. Exon(s) indicated by black outlines.
Copyright 2009, UCSF Pharmacogenetics of Membrane Transporters. All rights reserved.