Substrate In Vitro Evidence:
1. RLI (RNase L inhibitor) expression is not regulated by interferon action. RLI expression in reticulocyte extracts antagonizes the 2-5A binding ability and the nuclease activity of endogenous RNase L. The overexpression of RLI in HeLa cells inhibits IFN activity on encephalomyocarditis. RLI is the first described mediator of the 2-5A/RNase L pathway. Bisbal, C et al. JBC 1995 Jun 2, 270(22):13308-17 PMID 7539425.
2. RLI is induced during HIV-1 infection and downregulates the 2-5A/RNase L pathway in human T cells, leading to an increase in HIV replication. RLI antisense cDNA-expressing clones reverse the inhibition of RNase L activity and leads to a decrease in viral load. Martinand, C et al. J Virol 1999 Jan, 73(1):290-6 PMID 9847332.
3. RLI is transiently induced by dsRNA. Martinand, C et al. J Interferon Cytokine Res 1998 Dec, 18(12):1031-8 PMID 9877446.
Tissue Distribution Evidence:
1. Northern blot shows ubiquitous expression of two transcript forms but differences in levels of expression suggest a tissue-specific regulation. Aubry, F et al. FEBS Lett 1996 Feb 26, 381(1-2):135-9 PMID 8641422.
The heat map summarizes relative expression by tissue type
at two levels of tissue detail, e.g., 'Brain' and 'Brain - Amygdala'.
Choose among four calculated expression values, including mean and median RPKM
values, and quantile normalized (QN) distributions of these values.
(Note that differences between some distributions are subtle.)
The coloring is relative to the mean of all displayed values.
All values are log base 2. (See also PMT GTEx Expression Plotting.)
Click on a transcript or tissue to resort the data.
Transmembrane prediction: TOPO2 image is not available.
20141104 phase 3 variant call set of the 20130502 sequence freeze and alignments for SNPs and short indels (indels > 255 and structural variants are not included here). This variant set contains 2504 individuals from 26 populations (mouse over population column heading for population sizes). Showing gene variants in regions defined by NCBI RefSeq exons, putative promoter, and PMT resequencing assays. Note: Frequencies are calculated directly from reported genotypes and may vary from consensus frequencies reported by the 1000 Genomes project, which relied on additional data and the GATK tool Variant Quality Score Recalibrator.
dbSNP build 142.
Array availability: I - found on Illumina Human1M-Duo BeadChip (2011-04-21) A - found on Affymetrix Genome-Wide SNP Array 6.0 (2011-06-21)