UCSF Pharmacogenetics of Membrane Transporters
Gene View
Common Name:TAT1
HGNC Symbol:SLC16A10
HGNC Description:solute carrier family 16 (aromatic amino acid transporter), member 10
HGNC ID:17027
Superfamily:SLC
Chromosome:Chr.6(+): 111408728-111544608 GRCh37
Location:6q21-q22
OMIM:607550
OMIM Phenotype:None
Accessions:NM_018593
Nucleotide RefSeq:NM_018593
Protein RefSeq:NP_061063
Entrez:117247
Ensembl:ENSG00000112394
Isoforms:3
Evidence:Substrate In Vitro Evidence: L-tryptophan 32 Xenopus laevis oocytes L-tyrosine 32 Xenopus laevis oocytes L-phenylalanine 32 Xenopus laevis oocytes D-phenylalanine 32 Xenopus laevis oocytes L-dopa 32 Xenopus laevis oocytes Tissue Distribution Evidence: skeletal muscle 32 northern blot kidney 32 northern blot heart 32 northern blot placenta 32 northern blot human small intestine epithelium 32 RT-PCR
Tissues:skeletal muscle, kidney, heart, placenta, human small intestine epithelium
Type:protein-coding
Sets:V
PharmGKB ID:PA38197
HPRD ID:09613
Substrates:L-tryptophan, L-tyrosine, L-phenylalanine, D-phenylalanine, L-dopa
Trivial Names:TAT1, MCT10, PRO0813
Transcripts:NM_018593.4 [Chr.6(+): 111408781-111544608 GRCh37]
XM_005266818.1 [Chr.6(+): 111408728-111544223 GRCh37]
XM_005266819.1 [Chr.6(+): 111408728-111527858 GRCh37]
ENST00000368850 [Chr.6(+): 111498415-111552397 GRCh37]
ENST00000368851 [Chr.6(+): 111408781-111544223 GRCh37]
ENST00000419619 [Chr.6(+): 111493898-111499914 GRCh37]
ENST00000439288 [Chr.6(+): 111493898-111498915 GRCh37]
ENST00000465319 [Chr.6(+): 111493898-111498915 GRCh37]
Annotation History:View Events (20)

GTEx Expression by Gene and Transcript

The heat map summarizes relative expression by tissue type at two levels of tissue detail, e.g., 'Brain' and 'Brain - Amygdala'. Choose among four calculated expression values, including mean and median RPKM values, and quantile normalized (QN) distributions of these values. (Note that differences between some distributions are subtle.) The coloring is relative to the mean of all displayed values. All values are log base 2. (See also PMT GTEx Expression Plotting.) Click on a transcript or tissue to resort the data.

Tissues:
Expression values:
No expression data exists for SLC16A10.

Variant Data

View all PMT variants for SLC16A10 on UCSC Genome Browser
Showing SNP features for transcript:   
1000 Genomes  

20141104 phase 3 variant call set of the 20130502 sequence freeze and alignments for SNPs and short indels (indels > 255 and structural variants are not included here). This variant set contains 2504 individuals from 26 populations (mouse over population column heading for population sizes).
Showing gene variants in regions defined by NCBI RefSeq exons, putative promoter, and PMT resequencing assays.
Note: Frequencies are calculated directly from reported genotypes and may vary from consensus frequencies reported by the 1000 Genomes project, which relied on additional data and the GATK tool Variant Quality Score Recalibrator.
dbSNP build 142.
Array availability: I - found on Illumina Human1M-Duo BeadChip (2011-04-21)  A - found on Affymetrix Genome-Wide SNP Array 6.0 (2011-06-21)  
Download the SNP table data as a tab-delimited file.

Transmembrane prediction:

Non-synonymous amino acid changes shown in red, indels (insertions and deletions) in blue, and synonymous changes in green. Exon(s) indicated by black outlines.