UCSF Pharmacogenetics of Membrane Transporters
Gene View
Common Name:MCT3
HGNC Symbol:SLC16A3
HGNC Description:solute carrier family 16 (monocarboxylate transporter), member 3
HGNC ID:10924
Chromosome:Chr.17(+): 80186282-80197375 GRCh37
OMIM Phenotype:None
Nucleotide RefSeq:NM_001042422
Protein RefSeq:NP_001035887
Evidence:Substrate In Vitro Evidence: L-lactate, D-lactate, pyruvate, S-chloropropionate, R-chloropropionate, D,L-[pic]-hydroxybutyrate, L-[pic]-hydroxybutyrate, D-[pic]-hydroxybutyrate, acetoacetate, [pic]-ketobutyrate, [pic]-ketoisocaproate, and [pic]-ketoisovalerate were shown to substrates of MCT4 when expressed in X. laevis oocytes (Manning Fox JE, Meredith D, Halestrap AP. Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle. J Physiol 529 Pt 2:285-93, 2000) . Tissue Distribution Evidence: Northern blot analysis showed high expression of MCT3 in skeletal muscle, placenta, leukocytes, testis, and heart, and lower expression in lung, prostate, spleen, kidney, colon, small intestine, ovary and thymus (Price NT, Jackson VN, Halestrap AP. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. Biochem J 329 ( Pt 2):321-8, 1998).
Tissues:Skeletal muscle, placenta, leukocytes, testis, heart (high); lung, prostate, spleen, kidney, colon, small intestine, ovary, thymus (low)
PharmGKB ID:PA35815
HPRD ID:04854
Substrates:L-lactate, D-lactate, pyruvate, S-chloropropionate, R-chloropropionate, D,L-alpha-hydroxybutyrate, L-beta-hydroxybutyrate, D-beta-hydroxybutyrate, acetoacetate, alpha-ketobutyrate, alpha-ketoisocaproate, alpha-ketoisovalerate
Trivial Names:MCT3, MCT4, MCT 3, MCT 4, MCT-3, MCT-4
Transcripts:NM_001042422.2 [Chr.17(+): 80186282-80197375 GRCh37]
NM_001042423.2 [Chr.17(+): 80190108-80197375 GRCh37]
NM_004207.3 [Chr.17(+): 80186887-80197375 GRCh37]
NM_001206950.1 [Chr.17(+): 80186282-80197375 GRCh37]
NM_001206951.1 [Chr.17(+): 80192775-80197375 GRCh37]
NM_001206952.1 [Chr.17(+): 80193650-80197375 GRCh37]
ENST00000392339 [Chr.17(+): 80190144-80197369 GRCh37]
ENST00000392341 [Chr.17(+): 80186293-80197369 GRCh37]
ENST00000577650 [Chr.17(+): 80186936-80195196 GRCh37]
ENST00000578522 [Chr.17(+): 80192775-80195053 GRCh37]
ENST00000578574 [Chr.17(+): 80186938-80194771 GRCh37]
ENST00000578684 [Chr.17(+): 80186934-80195581 GRCh37]
ENST00000578810 [Chr.17(+): 80194350-80195292 GRCh37]
ENST00000579572 [Chr.17(+): 80186944-80195179 GRCh37]
ENST00000580098 [Chr.17(+): 80190108-80195351 GRCh37]
ENST00000580189 [Chr.17(+): 80192929-80195315 GRCh37]
ENST00000581287 [Chr.17(+): 80191563-80197962 GRCh37]
ENST00000581642 [Chr.17(+): 80186324-80194333 GRCh37]
ENST00000582715 [Chr.17(+): 80186969-80197357 GRCh37]
ENST00000582743 [Chr.17(+): 80186908-80197355 GRCh37]
ENST00000582946 [Chr.17(+): 80193650-80195137 GRCh37]
ENST00000583025 [Chr.17(+): 80195046-80219005 GRCh37]
ENST00000583237 [Chr.17(+): 80186297-80195303 GRCh37]
ENST00000583444 [Chr.17(+): 80186921-80189802 GRCh37]
ENST00000584689 [Chr.17(+): 80186273-80195520 GRCh37]
ENST00000584781 [Chr.17(+): 80186931-80195158 GRCh37]
Annotation History:View Events (4)

GTEx Expression by Gene and Transcript

The heat map summarizes relative expression by tissue type at two levels of tissue detail, e.g., 'Brain' and 'Brain - Amygdala'. Choose among four calculated expression values, including mean and median RPKM values, and quantile normalized (QN) distributions of these values. (Note that differences between some distributions are subtle.) The coloring is relative to the mean of all displayed values. All values are log base 2. (See also PMT GTEx Expression Plotting.) Click on a transcript or tissue to resort the data.

Expression values:
No expression data exists for SLC16A3.

Variant Data

View all PMT variants for SLC16A3 on UCSC Genome Browser
Showing SNP features for transcript:   
1000 Genomes  

20141104 phase 3 variant call set of the 20130502 sequence freeze and alignments for SNPs and short indels (indels > 255 and structural variants are not included here). This variant set contains 2504 individuals from 26 populations (mouse over population column heading for population sizes).
Showing gene variants in regions defined by NCBI RefSeq exons, putative promoter, and PMT resequencing assays.
Note: Frequencies are calculated directly from reported genotypes and may vary from consensus frequencies reported by the 1000 Genomes project, which relied on additional data and the GATK tool Variant Quality Score Recalibrator.
dbSNP build 142.
Array availability: I - found on Illumina Human1M-Duo BeadChip (2011-04-21)  A - found on Affymetrix Genome-Wide SNP Array 6.0 (2011-06-21)  
Download the SNP table data as a tab-delimited file.

Transmembrane prediction:

Non-synonymous amino acid changes shown in red, indels (insertions and deletions) in blue, and synonymous changes in green. Exon(s) indicated by black outlines.