|HGNC Description:||solute carrier family 16 (monocarboxylate transporter), member 8|
|Chromosome:||Chr.22(-): 38474144-38479170 GRCh37|
|Evidence:||Substrate In Vitro Evidence: The human MCT3 transporter has not been studied in heterologous expression systems. Chick MCT3 was shown to transport lactate using a yeast expression system (Grollman EF, Philp NJ, McPhie P, Ward RD, Sauer B. Determination of transport kinetics of chick MCT3 monocarboxylate transporter from retinal pigment epithelium by expression in genetically modified yeast. Biochemistry 39:9351-9357, 2000). . Tissue Distribution Evidence: Tissue distribution of SLC16A8 has not been studied in humans. In mouse, MCT3 expression is restricted to retinal pigment and choroid plexus epithelia as determined by Northern blot (Philp NJ, Yoon H, Lombardi L. Mouse MCT3 gene is expressed preferentially in retinal pigment and choroid plexus epithelia. Am J Physiol Cell Physiol 280(5):C1319-26, 2001).|
|Tissues:||Mice: retinal pigment and choroid plexus epithelia|
|Trivial Names:||MCT3, REMP|
|Transcripts:||NM_013356.2 [Chr.22(-): 38474144-38479170 GRCh37]||ENST00000320521 [Chr.22(-): 38474141-38479149 GRCh37]|
ENST00000427592 [Chr.22(-): 38477962-38480100 GRCh37]
ENST00000469516 [Chr.22(-): 38474141-38480100 GRCh37]
|Annotation History:||View Events (2)|
GTEx Expression by Gene and Transcript
The heat map summarizes relative expression by tissue type at two levels of tissue detail, e.g., 'Brain' and 'Brain - Amygdala'. Choose among four calculated expression values, including mean and median RPKM values, and quantile normalized (QN) distributions of these values. (Note that differences between some distributions are subtle.) The coloring is relative to the mean of all displayed values. All values are log base 2. (See also PMT GTEx Expression Plotting.) Click on a transcript or tissue to resort the data.
Showing gene variants in regions defined by NCBI RefSeq exons, putative promoter, and PMT resequencing assays.
Note: Frequencies are calculated directly from reported genotypes and may vary from consensus frequencies reported by the 1000 Genomes project, which relied on additional data and the GATK tool Variant Quality Score Recalibrator.
Non-synonymous amino acid changes shown in red, indels (insertions and deletions) in blue, and synonymous changes in green. Exon(s) indicated by black outlines.