Substrate In Vitro Evidence:
1. NPT-1 RNA injected into Xenopus oocytes resulted in Na+/Pi co-transport activity showing a high affinity for phosphate (Km 0.29 mM). Miyamoto, K et al. Biochem J. 1995 Jan 1, 305 (pt 1):81-5 PMID 7826357.
2. Mouse Npt1 RNA was injected into xenopus oocytes. Faropenem (an oral penem antibiotic) was transported (Km 0.77 mM) in an Na+ independent, Cl- dependent manner. Transport was significantly inhibited by benzylpenicillin, ampicillin, cephalexin, cefazolin (beta-lactam antibiotics), as well as indomethacin and furosemide. May play a role in the renal secretion of penem antibiotics. Uchino, H et al. Antimicrob Agents Chemother 2000 Mar, 44(3):574-7 PMID 10681320.
Tissue Distribution Evidence:
3. Northern blotting demonstrated that NPT-1 mRNA is expressed in renal cortex, liver, and brain. Miyamoto, K et al. Biochem J. 1995 Jan 1, 305 (pt 1):81-5 PMID 7826357.
The heat map summarizes relative expression by tissue type
at two levels of tissue detail, e.g., 'Brain' and 'Brain - Amygdala'.
Choose among four calculated expression values, including mean and median RPKM
values, and quantile normalized (QN) distributions of these values.
(Note that differences between some distributions are subtle.)
The coloring is relative to the mean of all displayed values.
All values are log base 2. (See also PMT GTEx Expression Plotting.)
Click on a transcript or tissue to resort the data.
Transmembrane prediction: TOPO2 image is not available.
20141104 phase 3 variant call set of the 20130502 sequence freeze and alignments for SNPs and short indels (indels > 255 and structural variants are not included here). This variant set contains 2504 individuals from 26 populations (mouse over population column heading for population sizes). Showing gene variants in regions defined by NCBI RefSeq exons, putative promoter, and PMT resequencing assays. Note: Frequencies are calculated directly from reported genotypes and may vary from consensus frequencies reported by the 1000 Genomes project, which relied on additional data and the GATK tool Variant Quality Score Recalibrator.
dbSNP build 142.
Array availability: I - found on Illumina Human1M-Duo BeadChip (2011-04-21) A - found on Affymetrix Genome-Wide SNP Array 6.0 (2011-06-21)