| Common Name: | EAAT2 |
| HGNC Symbol: | SLC1A2 |
| HGNC Description: | solute carrier family 1 (glial high affinity glutamate transporter), member 2 |
| HGNC ID: | 10940 |
| Chromosome: | Chr.11(-): 35229328-35397681 |
| Location: | 11p13-p12 |
| OMIM: | 600300 |
| OMIM Phenotype: | Amyotryphic lateral sclerosis |
| Accessions: | NM_004171 |
| Nucleotide RefSeq: | NM_004171 |
| Protein RefSeq: | NP_004162 |
| Entrez: | 6506 |
| Isoforms: | 1 |
| Evidence: | Substrate In Vitro Evidence: 1. L-Glu, D/L Asp Substrate In Vivo Evidence: 1. KO mice show lethal spontaneous epileptic seizures - Tanaka K et al, Science, 1997: 1699-702 Tissue Distribution Evidence: 1. Astrocytes (Northern), glial cells of brain (IHC) - Peghini P et al, EMBO Journal, 1997: 3822-3832 |
| Tissues: | Astrocytes |
| Type: | protein coding |
| Sets: | V |
| PharmGKB ID: | PA35827 |
| HPRD ID: | 02625 |
| Substrates: | L-Glu, D/L Asp |
| Trivial Names: | EAAT2, GLT-1 |
| Transcripts: | NM_004171 [Chr.11(-): 35229328-35397681] |
View on UCSC Genome Browser or Ensembl Genome Browser
Transmembrane prediction:
Non-synonymous amino acid changes shown in red, indels (insertions and deletions) in blue, and synonymous changes in green. Exon(s) indicated by black outlines.