| Common Name: | EAAT1 |
| HGNC Symbol: | SLC1A3 |
| HGNC Description: | solute carrier family 1 (glial high affinity glutamate transporter), member 3 |
| HGNC ID: | 10941 |
| Chromosome: | Chr.5(+): 36642446-36724191 |
| Location: | 5p13 |
| OMIM: | 600111 |
| OMIM Phenotype: | None |
| Accessions: | NM_004172 |
| Nucleotide RefSeq: | NM_004172 |
| Protein RefSeq: | NP_004163 |
| Entrez: | 6507 |
| Isoforms: | 1 |
| Evidence: | Substrate In Vitro Evidence: 1. L-Glu, D/L Asp Substrate In Vivo Evidence: 1. Selective inhibition by dihydrokainate and kainite, Arriza J et al, Journal of Neuroscience, 1994: 5559-5569 2. KO mice exhibited motor discoordination, Watase K et al, European Journal of Neuroscience, 1998: 976-988 Tissue Distribution Evidence: 1. Bergmann glia cells, hippocampus, cortex - IHC, in situ hybridization - Peghini P et al, EMBO Journal, 1997: 3822-3832 |
| Tissues: | Bergmann glia cells, hippocampus, cortex |
| Type: | protein coding |
| Sets: | V |
| PharmGKB ID: | PA35828 |
| HPRD ID: | 02523 |
| Substrates: | L-Glu, D/L Asp |
| Trivial Names: | EA6, EAAT1, GLAST, GLAST1, FLJ25094 |
| Transcripts: | NM_004172 [Chr.5(+): 36642214-36724193] |
View on UCSC Genome Browser or Ensembl Genome Browser
Transmembrane prediction:
Non-synonymous amino acid changes shown in red, indels (insertions and deletions) in blue, and synonymous changes in green. Exon(s) indicated by black outlines.