|HGNC Description:||solute carrier family 24 (sodium/potassium/calcium exchanger), member 3|
|Chromosome:||Chr.20(+): 19193290-19703541 GRCh37|
|Evidence:||Substrate In Vitro Evidence: In HEK 293 cells transiently transfected with NCKX3, this transporter was shown to be a potassium-dependent sodium/calcium exchanger (Kraev A, Quednau BD, Leach S, Li XF, Dong H, Winkfein R, Perizzolo M, Cai X, Yang R, Philipson KD, Lytton J. Molecular cloning of a third member of the potassium-dependent sodium-calcium exchanger gene family, NCKX3. J Biol Chem 276(25): 23161-72, 2001). Tissue Distribution Evidence: Northern blot analysis revealed NCKX3 mRNA expression in several regions of human brain, including cerebral cortex, cerebellum, medulla, and putamen (Kraev A, Quednau BD, Leach S, Li XF, Dong H, Winkfein R, Perizzolo M, Cai X, Yang R, Philipson KD, Lytton J. Molecular cloning of a third member of the potassium-dependent sodium-calcium exchanger gene family, NCKX3. J Biol Chem 276(25): 23161-72, 2001).|
|Tissues:||Brain (cerebral cortex, cerebellum, medulla, putamen)|
|Transcripts:||NM_020689.3 [Chr.20(+): 19193290-19703541 GRCh37]||ENST00000328041 [Chr.20(+): 19193290-19703581 GRCh37]|
GTEx Expression by Gene and Transcript
The heat map summarizes relative expression by tissue type at two levels of tissue detail, e.g., 'Brain' and 'Brain - Amygdala'. Choose among four calculated expression values, including mean and median RPKM values, and quantile normalized (QN) distributions of these values. (Note that differences between some distributions are subtle.) The coloring is relative to the mean of all displayed values. All values are log base 2. (See also PMT GTEx Expression Plotting.) Click on a transcript or tissue to resort the data.
Showing gene variants in regions defined by NCBI RefSeq exons, putative promoter, and PMT resequencing assays.
Note: Frequencies are calculated directly from reported genotypes and may vary from consensus frequencies reported by the 1000 Genomes project, which relied on additional data and the GATK tool Variant Quality Score Recalibrator.
Non-synonymous amino acid changes shown in red, indels (insertions and deletions) in blue, and synonymous changes in green. Exon(s) indicated by black outlines.