|HGNC Description:||solute carrier family 26 (anion exchanger), member 1|
|Chromosome:||Chr.4(-): 972861-987228 GRCh37|
|Evidence:||Substrate In Vitro Evidence: When expressed in X. laevis oocytes, hsat-1 facilitated the transport of sulfate, chloride, and oxalate; sulfate transport was inhibited by DIDS, phenol red, thiosulfate, molybdate, tungstate, and selenate (Regeer RR, Lee A, Markovich D. Characterization of the human sulfate anion transporter (hsat-1) protein and gene (SAT1; SLC26A1). DNA Cell Biol 22(2): 107-17. 2003). Tissue Distribution Evidence: By PCR from a human multiple-tissue cDNA panel, SAT1 was found to be expressed most highly in kidney and liver, and to a lesser extent in pancreas, testis, prostate, spleen, colon, brain, thymus, and lung (Regeer RR, Lee A, Markovich D. Characterization of the human sulfate anion transporter (hsat-1) protein and gene (SAT1; SLC26A1). DNA Cell Biol 22(2): 107-17. 2003).|
|Tissues:||Kidney, liver (high); pancreas, testis, prostate, spleen, colon, brain, thymus, lung (low)|
|Substrates:||Sulfate, chloride, oxalate|
|Trivial Names:||EDM4, SAT1, SAT-1|
|Transcripts:||NM_022042.3 [Chr.4(-): 981445-987228 GRCh37]|
NM_134425.2 [Chr.4(-): 972861-987228 GRCh37]
NM_213613.3 [Chr.4(-): 981445-987228 GRCh37]
|ENST00000361661 [Chr.4(-): 981445-987224 GRCh37]|
ENST00000398516 [Chr.4(-): 981785-987228 GRCh37]
ENST00000398520 [Chr.4(-): 972861-987164 GRCh37]
ENST00000513138 [Chr.4(-): 984409-984983 GRCh37]
|Annotation History:||View Events (17)|
GTEx Expression by Gene and Transcript
The heat map summarizes relative expression by tissue type at two levels of tissue detail, e.g., 'Brain' and 'Brain - Amygdala'. Choose among four calculated expression values, including mean and median RPKM values, and quantile normalized (QN) distributions of these values. (Note that differences between some distributions are subtle.) The coloring is relative to the mean of all displayed values. All values are log base 2. (See also PMT GTEx Expression Plotting.) Click on a transcript or tissue to resort the data.
Showing gene variants in regions defined by NCBI RefSeq exons, putative promoter, and PMT resequencing assays.
Note: Frequencies are calculated directly from reported genotypes and may vary from consensus frequencies reported by the 1000 Genomes project, which relied on additional data and the GATK tool Variant Quality Score Recalibrator.
Transmembrane prediction: TOPO2 image is not available.