UCSF Pharmacogenetics of Membrane Transporters
Gene View
Common Name:SLC26A7
HGNC Symbol:SLC26A7
HGNC Description:solute carrier family 26 (anion exchanger), member 7
HGNC ID:14467
Superfamily:SLC
Chromosome:Chr.8(+): 92261508-92410378 GRCh37
Location:8q23
OMIM:608479
OMIM Phenotype:None
Accessions:NM_052832
Nucleotide RefSeq:NM_052832
Protein RefSeq:NP_439897
Entrez:115111
Ensembl:ENSG00000147606
Isoforms:5
Evidence:Substrate In Vitro Evidence: Expression of SLC26A7 in X. laevis oocytes showed this protein to be a transporter of chloride, sulfate, and oxalate (Lohi H, Kujala M, Makela S, Lehtonen E, Kestila M, Saarialho-Kere U, Markovich D, Kere J. Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9. J Biol Chem 277(16): 14246-54, 2002). Tissue Distribution Evidence: SLC26A7 was found to be expressed almost exclusively in kidney by Northern blot (Vincourt JB, Jullien D, Kossida S, Amalric F, Girard JP. Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney. Genomics 79(2): 249-56, 2002; Lohi H, Kujala M, Makela S, Lehtonen E, Kestila M, Saarialho-Kere U, Markovich D, Kere J. Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9. J Biol Chem 277(16): 14246-54, 2002).
Tissues:Kidney
Type:protein-coding
Sets:V
PharmGKB ID:PA37884
HPRD ID:10533
Substrates:Chloride, sulfate, oxalate
Trivial Names:SUT2
Transcripts:NM_052832.2 [Chr.8(+): 92261516-92410378 GRCh37]
NM_134266.1 [Chr.8(+): 92261516-92406946 GRCh37]
XM_005250775.1 [Chr.8(+): 92261508-92406975 GRCh37]
XM_005250774.1 [Chr.8(+): 92261508-92406975 GRCh37]
XM_005250776.1 [Chr.8(+): 92261508-92356467 GRCh37]
ENST00000276609 [Chr.8(+): 92261516-92410378 GRCh37]
ENST00000309536 [Chr.8(+): 92261535-92406946 GRCh37]
ENST00000517930 [Chr.8(+): 92369476-92406064 GRCh37]
ENST00000520249 [Chr.8(+): 92355258-92410366 GRCh37]
ENST00000520818 [Chr.8(+): 92307852-92352886 GRCh37]
ENST00000522181 [Chr.8(+): 92221722-92407877 GRCh37]
ENST00000522862 [Chr.8(+): 92221723-92330587 GRCh37]
ENST00000523719 [Chr.8(+): 92221728-92407984 GRCh37]
Annotation History:View Events (28)

GTEx Expression by Gene and Transcript

The heat map summarizes relative expression by tissue type at two levels of tissue detail, e.g., 'Brain' and 'Brain - Amygdala'. Choose among four calculated expression values, including mean and median RPKM values, and quantile normalized (QN) distributions of these values. (Note that differences between some distributions are subtle.) The coloring is relative to the mean of all displayed values. All values are log base 2. (See also PMT GTEx Expression Plotting.) Click on a transcript or tissue to resort the data.

Tissues:
Expression values:
No expression data exists for SLC26A7.

Variant Data

View all PMT variants for SLC26A7 on UCSC Genome Browser
Showing SNP features for transcript:   
1000 Genomes  

20141104 phase 3 variant call set of the 20130502 sequence freeze and alignments for SNPs and short indels (indels > 255 and structural variants are not included here). This variant set contains 2504 individuals from 26 populations (mouse over population column heading for population sizes).
Showing gene variants in regions defined by NCBI RefSeq exons, putative promoter, and PMT resequencing assays.
Note: Frequencies are calculated directly from reported genotypes and may vary from consensus frequencies reported by the 1000 Genomes project, which relied on additional data and the GATK tool Variant Quality Score Recalibrator.
dbSNP build 142.
Array availability: I - found on Illumina Human1M-Duo BeadChip (2011-04-21)  A - found on Affymetrix Genome-Wide SNP Array 6.0 (2011-06-21)  
Download the SNP table data as a tab-delimited file.

Transmembrane prediction:

Non-synonymous amino acid changes shown in red, indels (insertions and deletions) in blue, and synonymous changes in green. Exon(s) indicated by black outlines.