| Common Name: | GLUT10 |
| HGNC Symbol: | SLC2A10 |
| HGNC Description: | solute carrier family 2 (facilitated glucose transporter), member 10 |
| HGNC ID: | 13444 |
| Chromosome: | Chr.20(+): 44771686-44798393 |
| Location: | 20q13.1 |
| OMIM: | 606145 |
| OMIM Phenotype: | None |
| Accessions: | AF248053,AF321240 |
| Nucleotide RefSeq: | NM_030777 |
| Protein RefSeq: | NP_110404 |
| Entrez: | 81031 |
| Isoforms: | 1 |
| Evidence: | Substrate In Vitro Evidence: 2-deoxyglucose, D-galactose, D-glucose (Xenopus oocytes) Dawson PA, Mychaleckyj JC, Fossey SC, Mihic SJ, Craddock AL, Bowden DW. Sequence and functional analysis of GLUT10: a glucose transporter in the Type 2 diabetes-linked region of chromosome 20q12-13.1. Mol Genet Metab. 2001 Sep-Oct;74(1-2):186-99. GLUT10 gene has been localized to human chromosome 20q12-q13.1, one of the genomic loci associated with non-insulin dependent diabetes mellitus (NIDDM). McVie-Wylie, A. J.; Lamson, D. R.; Chen, Y. T. Molecular cloning of a novel member of the GLUT family of transporters, SLC2A10 (GLUT10), localized on chromosome 20q13.1: a candidate gene for NIDDM susceptibility. Genomics 72: 113-117, 2001. Substrate In Vivo Evidence: SLC2A10 may not contribute substantially to the pathogenesis of type 2 diabetes. However, the Ala206Thr polymorphism may be related to the interindividual variation in fasting and oral glucose-induced serum insulin levels. Andersen G, Rose CS, Hamid YH, Drivsholm T, Borch-Johnsen K, Hansen T, Pedersen O. Genetic variation of the GLUT10 glucose transporter (SLC2A10) and relationships to type 2 diabetes and intermediary traits. Diabetes 52: 2445-8, 2003. Tissue Distribution Evidence: Northern hybridization analysis identified a single 4.4-kb transcript for GLUT10 in human heart, lung, brain, liver, skeletal muscle, pancreas, placenta, and kidney. By RT-PCR analysis, GLUT10 mRNA was also detected in fetal brain and liver. Dawson PA, Mychaleckyj JC, Fossey SC, Mihic SJ, Craddock AL, Bowden DW. Sequence and functional analysis of GLUT10: a glucose transporter in the Type 2 diabetes-linked region of chromosome 20q12-13.1. Mol Genet Metab. 2001 Sep-Oct;74(1-2):186-99. A major 4.3-kb transcript with highest levels of expression in liver and pancreas and lower levels of expression in a variety of tissues (Northern blotting) McVie-Wylie, A. J.; Lamson, D. R.; Chen, Y. T. Molecular cloning of a novel member of the GLUT family of transporters, SLC2A10 (GLUT10), localized on chromosome 20q13.1: a candidate gene for NIDDM susceptibility. Genomics 72: 113-117, 2001. |
| Tissues: | heart, lung, brain, liver, skeletal muscle, pancreas, placenta, and kidney |
| Type: | protein coding |
| Sets: | 0 |
| PharmGKB ID: | PA37769 |
| HPRD ID: | 05851 |
| Substrates: | 2-deoxyglucose, D-galactose, D-glucose |
| Trivial Names: | ATS, GLUT10, MGC126706 |
| Transcripts: | NM_030777 [Chr.20(+): 44771686-44798393] |
View on UCSC Genome Browser or Ensembl Genome Browser
Transmembrane prediction:
Non-synonymous amino acid changes shown in red, indels (insertions and deletions) in blue, and synonymous changes in green. Exon(s) indicated by black outlines.