UCSF Pharmacogenetics of Membrane Transporters
Gene View
Common Name:GLUT10
HGNC Symbol:SLC2A10
HGNC Description:solute carrier family 2 (facilitated glucose transporter), member 10
HGNC ID:13444
Superfamily:SLC
Chromosome:Chr.20(+): 45338279-45364986 GRCh37
Location:20q13.1
OMIM:606145
OMIM Phenotype:None
Accessions:AF248053,AF321240
Nucleotide RefSeq:NM_030777
Protein RefSeq:NP_110404
Entrez:81031
Ensembl:ENSG00000197496
Isoforms:1
Evidence:Substrate In Vitro Evidence: 2-deoxyglucose, D-galactose, D-glucose (Xenopus oocytes) Dawson PA, Mychaleckyj JC, Fossey SC, Mihic SJ, Craddock AL, Bowden DW. Sequence and functional analysis of GLUT10: a glucose transporter in the Type 2 diabetes-linked region of chromosome 20q12-13.1. Mol Genet Metab. 2001 Sep-Oct;74(1-2):186-99. GLUT10 gene has been localized to human chromosome 20q12-q13.1, one of the genomic loci associated with non-insulin dependent diabetes mellitus (NIDDM). McVie-Wylie, A. J.; Lamson, D. R.; Chen, Y. T. Molecular cloning of a novel member of the GLUT family of transporters, SLC2A10 (GLUT10), localized on chromosome 20q13.1: a candidate gene for NIDDM susceptibility. Genomics 72: 113-117, 2001. Substrate In Vivo Evidence: SLC2A10 may not contribute substantially to the pathogenesis of type 2 diabetes. However, the Ala206Thr polymorphism may be related to the interindividual variation in fasting and oral glucose-induced serum insulin levels. Andersen G, Rose CS, Hamid YH, Drivsholm T, Borch-Johnsen K, Hansen T, Pedersen O. Genetic variation of the GLUT10 glucose transporter (SLC2A10) and relationships to type 2 diabetes and intermediary traits. Diabetes 52: 2445-8, 2003. Tissue Distribution Evidence: Northern hybridization analysis identified a single 4.4-kb transcript for GLUT10 in human heart, lung, brain, liver, skeletal muscle, pancreas, placenta, and kidney. By RT-PCR analysis, GLUT10 mRNA was also detected in fetal brain and liver. Dawson PA, Mychaleckyj JC, Fossey SC, Mihic SJ, Craddock AL, Bowden DW. Sequence and functional analysis of GLUT10: a glucose transporter in the Type 2 diabetes-linked region of chromosome 20q12-13.1. Mol Genet Metab. 2001 Sep-Oct;74(1-2):186-99. A major 4.3-kb transcript with highest levels of expression in liver and pancreas and lower levels of expression in a variety of tissues (Northern blotting) McVie-Wylie, A. J.; Lamson, D. R.; Chen, Y. T. Molecular cloning of a novel member of the GLUT family of transporters, SLC2A10 (GLUT10), localized on chromosome 20q13.1: a candidate gene for NIDDM susceptibility. Genomics 72: 113-117, 2001.
Tissues:heart, lung, brain, liver, skeletal muscle, pancreas, placenta, and kidney
Type:protein-coding
Sets:0
PharmGKB ID:PA37769
HPRD ID:05851
Substrates:2-deoxyglucose, D-galactose, D-glucose
Trivial Names:ATS, GLUT10
Transcripts:NM_030777.3 [Chr.20(+): 45338279-45364986 GRCh37]
ENST00000359271 [Chr.20(+): 45338126-45364965 GRCh37]
ENST00000486000 [Chr.20(+): 45338338-45339075 GRCh37]

GTEx Expression by Gene and Transcript

The heat map summarizes relative expression by tissue type at two levels of tissue detail, e.g., 'Brain' and 'Brain - Amygdala'. Choose among four calculated expression values, including mean and median RPKM values, and quantile normalized (QN) distributions of these values. (Note that differences between some distributions are subtle.) The coloring is relative to the mean of all displayed values. All values are log base 2. (See also PMT GTEx Expression Plotting.) Click on a transcript or tissue to resort the data.

Tissues:
Expression values:
No expression data exists for SLC2A10.

Variant Data

View all PMT variants for SLC2A10 on UCSC Genome Browser
Showing SNP features for transcript: NM_030777  
1000 Genomes  

20141104 phase 3 variant call set of the 20130502 sequence freeze and alignments for SNPs and short indels (indels > 255 and structural variants are not included here). This variant set contains 2504 individuals from 26 populations (mouse over population column heading for population sizes).
Showing gene variants in regions defined by NCBI RefSeq exons, putative promoter, and PMT resequencing assays.
Note: Frequencies are calculated directly from reported genotypes and may vary from consensus frequencies reported by the 1000 Genomes project, which relied on additional data and the GATK tool Variant Quality Score Recalibrator.
dbSNP build 142.
Array availability: I - found on Illumina Human1M-Duo BeadChip (2011-04-21)  A - found on Affymetrix Genome-Wide SNP Array 6.0 (2011-06-21)  
Download the SNP table data as a tab-delimited file.

Transmembrane prediction:

Non-synonymous amino acid changes shown in red, indels (insertions and deletions) in blue, and synonymous changes in green. Exon(s) indicated by black outlines.