UCSF Pharmacogenetics of Membrane Transporters
Gene View
Common Name:GLUT11
HGNC Symbol:SLC2A11
HGNC Description:solute carrier family 2 (facilitated glucose transporter), member 11
HGNC ID:14239
Superfamily:SLC
Chromosome:Chr.22(+): 24199059-24227738 GRCh37
Location:22q11.23
OMIM:610367
OMIM Phenotype:None
Accessions:AF443201
Nucleotide RefSeq:NM_001024938
Protein RefSeq:NP_001020109
Entrez:66035
Ensembl:ENSG00000133460
Isoforms:3
Evidence:Substrate In Vitro Evidence: Glucose (Liposome reconstitution functional assay, GLUT11 transfected COS-7 cells) Wu,X., Li,W., Sharma,V., Godzik,A. and Freeze,H.H. Cloning and characterization of glucose transporter 11, a novel sugar transporter that is alternatively spliced in various tissues. Mol. Genet. Metab. 76 (1), 37-45 (2002) Doege,H., Bocianski,A., Scheepers,A., Axer,H., Eckel,J., Joost,H.G. and Schurmann,A. Characterization of human glucose transporter (GLUT) 11 (encoded by SLC2A11), a novel sugar-transport facilitator specifically expressed in heart and skeletal muscle. Biochem. J. 359 (Pt 2), 443-449 (2001) Tissue Distribution Evidence: Northern blot analysis showed that GLUT11 mRNA is expressed in a number of tissues and most abundantly in the skeletal muscle and heart. RT-PCR assay showed that GLUT11 is alternatively spliced and the two isoforms are distributed differently in various tissues. Wu,X., Li,W., Sharma,V., Godzik,A. and Freeze,H.H. Cloning and characterization of glucose transporter 11, a novel sugar transporter that is alternatively spliced in various tissues. Mol. Genet. Metab. 76 (1), 37-45 (2002) In human tissues, a 7.2 kb transcript of GLUT11 was detected exclusively in heart and skeletal muscle. (Northern blotting) Doege,H., Bocianski,A., Scheepers,A., Axer,H., Eckel,J., Joost,H.G. and Schurmann,A. Characterization of human glucose transporter (GLUT) 11 (encoded by SLC2A11), a novel sugar-transport facilitator specifically expressed in heart and skeletal muscle. Biochem. J. 359 (Pt 2), 443-449 (2001).
Tissues:a number of tissues and most abundantly in the skeletal muscle and heart
Type:protein-coding
Sets:0
PharmGKB ID:PA37861
HPRD ID:11571
Substrates:Glucose
Trivial Names:GLUT10, GLUT11
Transcripts:NM_001024938.2 [Chr.22(+): 24199059-24227738 GRCh37]
NM_001024939.2 [Chr.22(+): 24200041-24227738 GRCh37]
NM_030807.3 [Chr.22(+): 24199059-24227738 GRCh37]
ENST00000255830 [Chr.22(+): 24199144-24227120 GRCh37]
ENST00000316185 [Chr.22(+): 24200150-24227054 GRCh37]
ENST00000345044 [Chr.22(+): 24198890-24228496 GRCh37]
ENST00000398356 [Chr.22(+): 24199059-24227723 GRCh37]
ENST00000403208 [Chr.22(+): 24199050-24212369 GRCh37]
ENST00000405286 [Chr.22(+): 24199138-24225138 GRCh37]
ENST00000405340 [Chr.22(+): 24200106-24227740 GRCh37]
ENST00000405847 [Chr.22(+): 24199121-24219515 GRCh37]
ENST00000418102 [Chr.22(+): 24199658-24217376 GRCh37]
ENST00000423972 [Chr.22(+): 24199604-24219474 GRCh37]
ENST00000436643 [Chr.22(+): 24200082-24219359 GRCh37]
ENST00000440493 [Chr.22(+): 24199149-24208993 GRCh37]
ENST00000461809 [Chr.22(+): 24200148-24227723 GRCh37]
ENST00000467660 [Chr.22(+): 24199133-24225139 GRCh37]
ENST00000472526 [Chr.22(+): 24220045-24226971 GRCh37]
ENST00000473357 [Chr.22(+): 24222596-24225494 GRCh37]
ENST00000473740 [Chr.22(+): 24199187-24217398 GRCh37]
ENST00000482576 [Chr.22(+): 24217347-24225139 GRCh37]
ENST00000486907 [Chr.22(+): 24225147-24227723 GRCh37]
ENST00000489322 [Chr.22(+): 24199144-24227738 GRCh37]
ENST00000491948 [Chr.22(+): 24200062-24210983 GRCh37]
ENST00000492516 [Chr.22(+): 24199523-24204512 GRCh37]
Annotation History:View Events (2)

GTEx Expression by Gene and Transcript

The heat map summarizes relative expression by tissue type at two levels of tissue detail, e.g., 'Brain' and 'Brain - Amygdala'. Choose among four calculated expression values, including mean and median RPKM values, and quantile normalized (QN) distributions of these values. (Note that differences between some distributions are subtle.) The coloring is relative to the mean of all displayed values. All values are log base 2. (See also PMT GTEx Expression Plotting.) Click on a transcript or tissue to resort the data.

Tissues:
Expression values:
No expression data exists for SLC2A11.

Variant Data

View all PMT variants for SLC2A11 on UCSC Genome Browser
Showing SNP features for transcript:   
1000 Genomes  

20141104 phase 3 variant call set of the 20130502 sequence freeze and alignments for SNPs and short indels (indels > 255 and structural variants are not included here). This variant set contains 2504 individuals from 26 populations (mouse over population column heading for population sizes).
Showing gene variants in regions defined by NCBI RefSeq exons, putative promoter, and PMT resequencing assays.
Note: Frequencies are calculated directly from reported genotypes and may vary from consensus frequencies reported by the 1000 Genomes project, which relied on additional data and the GATK tool Variant Quality Score Recalibrator.
dbSNP build 142.
Array availability: I - found on Illumina Human1M-Duo BeadChip (2011-04-21)  A - found on Affymetrix Genome-Wide SNP Array 6.0 (2011-06-21)  
Download the SNP table data as a tab-delimited file.

Transmembrane prediction:

Non-synonymous amino acid changes shown in red, indels (insertions and deletions) in blue, and synonymous changes in green. Exon(s) indicated by black outlines.