| Common Name: | GLUT11 |
| HGNC Symbol: | SLC2A11 |
| HGNC Description: | solute carrier family 2 (facilitated glucose transporter), member 11 |
| HGNC ID: | 14239 |
| Chromosome: | Chr.22(+): 22529059-22557390 |
| Location: | 22q11.2 |
| OMIM: | 610367 |
| OMIM Phenotype: | None |
| Accessions: | AF443201 |
| Nucleotide RefSeq: | NM_001024938 |
| Protein RefSeq: | NP_001020109 |
| Entrez: | 66035 |
| Isoforms: | 3 |
| Evidence: | Substrate In Vitro Evidence: Glucose (Liposome reconstitution functional assay, GLUT11 transfected COS-7 cells) Wu,X., Li,W., Sharma,V., Godzik,A. and Freeze,H.H. Cloning and characterization of glucose transporter 11, a novel sugar transporter that is alternatively spliced in various tissues. Mol. Genet. Metab. 76 (1), 37-45 (2002) Doege,H., Bocianski,A., Scheepers,A., Axer,H., Eckel,J., Joost,H.G. and Schurmann,A. Characterization of human glucose transporter (GLUT) 11 (encoded by SLC2A11), a novel sugar-transport facilitator specifically expressed in heart and skeletal muscle. Biochem. J. 359 (Pt 2), 443-449 (2001) Tissue Distribution Evidence: Northern blot analysis showed that GLUT11 mRNA is expressed in a number of tissues and most abundantly in the skeletal muscle and heart. RT-PCR assay showed that GLUT11 is alternatively spliced and the two isoforms are distributed differently in various tissues. Wu,X., Li,W., Sharma,V., Godzik,A. and Freeze,H.H. Cloning and characterization of glucose transporter 11, a novel sugar transporter that is alternatively spliced in various tissues. Mol. Genet. Metab. 76 (1), 37-45 (2002) In human tissues, a 7.2 kb transcript of GLUT11 was detected exclusively in heart and skeletal muscle. (Northern blotting) Doege,H., Bocianski,A., Scheepers,A., Axer,H., Eckel,J., Joost,H.G. and Schurmann,A. Characterization of human glucose transporter (GLUT) 11 (encoded by SLC2A11), a novel sugar-transport facilitator specifically expressed in heart and skeletal muscle. Biochem. J. 359 (Pt 2), 443-449 (2001). |
| Tissues: | a number of tissues and most abundantly in the skeletal muscle and heart |
| Type: | protein coding |
| Sets: | 0 |
| PharmGKB ID: | PA37861 |
| HPRD ID: | 11571 |
| Substrates: | Glucose |
| Trivial Names: | GLUT10, GLUT11, MGC118830, MGC118833, SLC2A11-a, SLC2A11-c |
| Transcripts: | NM_001024938 [Chr.22(+): 22529059-22557738] NM_001024939 [Chr.22(+): 22530041-22557738] NM_030807 [Chr.22(+): 22529059-22557738] |
View on UCSC Genome Browser or Ensembl Genome Browser
Transmembrane prediction:
Non-synonymous amino acid changes shown in red, indels (insertions and deletions) in blue, and synonymous changes in green. Exon(s) indicated by black outlines.