| Common Name: | GLUT12 |
| HGNC Symbol: | SLC2A12 |
| HGNC Description: | solute carrier family 2 (facilitated glucose transporter), member 12 |
| HGNC ID: | 18067 |
| Chromosome: | Chr.6(-): 134350412-134415482 |
| Location: | 6q23.2 |
| OMIM: | 610372 |
| OMIM Phenotype: | None |
| Accessions: | AY046419 |
| Nucleotide RefSeq: | NM_145176 |
| Protein RefSeq: | NP_660159 |
| Entrez: | 154091 |
| Isoforms: | 1 |
| Evidence: | Substrate In Vitro Evidence: 1. GLUT12 facilitates transport of glucose (D-glucose>D-galactose>D-fructose>L-glucose) in the Xenopus laevis oocyte expression system. Rogers, S et al. Biochem Biophys Res Comm 2003 Aug 29, 308(3):422-6. Tissue Distribution Evidence: 1. Cloned from MCF7 breast cancer cell line. Also expressed in invasive human breast tumors (IHC, RT-PCR). Rogers, S. et al. Cancer Lett 2003 Apr 25, 193(2):225-33 PMID 12706881. 2. Two-step RT-PCR demonstrated expression of mouse GLUT12 in murine adipose tissue (although no expression in NIH3T3 cells). Human GLUT12 was found in human adipose tissue. Wood, IS; Hunter, L; Trayhurn, P. Biochem Biophys Res Comm 2003 Aug 15, 308(1):43-9 PMID 12890477. 3. Immunohistology studies demonstrated a dynamic spatial and temporal expression pattern for GLUT12 in human placenta. Gude, NM et al. Placenta 2003 May, 24(5):566-70 PMID 12744934. |
| Tissues: | malignant breast tumors, adipose tissue, placenta |
| Type: | protein coding |
| Sets: | 0 |
| PharmGKB ID: | PA38288 |
| HPRD ID: | 11572 |
| Substrates: | glucose |
| Trivial Names: | GLUT8, GLUT12 |
| Transcripts: | NM_145176 [Chr.6(-): 134350412-134415482] |
View on UCSC Genome Browser or Ensembl Genome Browser
Transmembrane prediction:
Non-synonymous amino acid changes shown in red, indels (insertions and deletions) in blue, and synonymous changes in green. Exon(s) indicated by black outlines.