| Common Name: | GLUT5 |
| HGNC Symbol: | SLC2A5 |
| HGNC Description: | solute carrier family 2 (facilitated glucose/fructose transporter), member 5 |
| HGNC ID: | 11010 |
| Chromosome: | Chr.1(-): 9019594-9052257 |
| Location: | 1p36.2 |
| OMIM: | 138230 |
| OMIM Phenotype: | None |
| Accessions: | M55531 |
| Nucleotide RefSeq: | NM_003039 |
| Protein RefSeq: | NP_003030 |
| Entrez: | 6518 |
| Isoforms: | 1 |
| Evidence: | Substrate In Vitro Evidence: Fructose, 2-deoxyglucose, D-glucose (Xenopus oocytes) Burant, C. F.; Takeda, J.; Brot-Laroche, E.; Bell, G. I.; Davidson, N. O. Fructose transporter in human spermatozoa and small intestine is GLUT5. J. Biol. Chem. 267: 14523-14526, 1992. Kayano, T.; Burant, C. F.; Fukumoto, H.; Gould, G. W.; Fan, Y. S.; Eddy, R. L.; Byers, M. G.; Shows, T. B.; Seino, S.; Bell, G. I. Human facilitative glucose transporters: isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6). J. Biol. Chem. 265: 13276-13282, 1990. Substrate In Vivo Evidence: Fructose, Glucose Monteiro IM, Jiang L, Ferraris RP. Dietary modulation of intestinal fructose transport and GLUT5 mRNA expression in hypothyroid rat pups. J Pediatr Gastroenterol Nutr. 29(5): 563-70, 1999. Tissue Distribution Evidence: GLUT5 mRNA is expressed at highest levels in small intestine and testis and at much lower levels in kidney, skeletal muscle, and adipose tissue. (Northern blotting) Burant, C. F.; Takeda, J.; Brot-Laroche, E.; Bell, G. I.; Davidson, N. O. Fructose transporter in human spermatozoa and small intestine is GLUT5. J. Biol. Chem. 267: 14523-14526, 1992. Kayano, T.; Burant, C. F.; Fukumoto, H.; Gould, G. W.; Fan, Y. S.; Eddy, R. L.; Byers, M. G.; Shows, T. B.; Seino, S.; Bell, G. I. Human facilitative glucose transporters: isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6). J. Biol. Chem. 265: 13276-13282, 1990. |
| Tissues: | High in small intestine and testis; low in kidney, skeletal muscle, and adipose tissue |
| Type: | protein coding |
| Sets: | 0 |
| PharmGKB ID: | PA35880 |
| HPRD ID: | 00690 |
| Substrates: | Fructose, 2-deoxyglucose, D-glucose |
| Trivial Names: | GLUT5 |
| Transcripts: | NM_003039 [Chr.1(-): 9019594-9052257] |
View on UCSC Genome Browser or Ensembl Genome Browser
Transmembrane prediction:
Non-synonymous amino acid changes shown in red, indels (insertions and deletions) in blue, and synonymous changes in green. Exon(s) indicated by black outlines.