UCSF Pharmacogenetics of Membrane Transporters
Gene View
Common Name:GLUT5
HGNC Symbol:SLC2A5
HGNC Description:solute carrier family 2 (facilitated glucose/fructose transporter), member 5
HGNC ID:11010
Superfamily:SLC
Chromosome:Chr.1(-): 9097005-9131763 GRCh37
Location:1p36.2
OMIM:138230
OMIM Phenotype:None
Accessions:M55531
Nucleotide RefSeq:NM_003039
Protein RefSeq:NP_003030
Entrez:6518
Ensembl:ENSG00000142583
Isoforms:4
Evidence:Substrate In Vitro Evidence: Fructose, 2-deoxyglucose, D-glucose (Xenopus oocytes) Burant, C. F.; Takeda, J.; Brot-Laroche, E.; Bell, G. I.; Davidson, N. O. Fructose transporter in human spermatozoa and small intestine is GLUT5. J. Biol. Chem. 267: 14523-14526, 1992. Kayano, T.; Burant, C. F.; Fukumoto, H.; Gould, G. W.; Fan, Y. S.; Eddy, R. L.; Byers, M. G.; Shows, T. B.; Seino, S.; Bell, G. I. Human facilitative glucose transporters: isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6). J. Biol. Chem. 265: 13276-13282, 1990. Substrate In Vivo Evidence: Fructose, Glucose Monteiro IM, Jiang L, Ferraris RP. Dietary modulation of intestinal fructose transport and GLUT5 mRNA expression in hypothyroid rat pups. J Pediatr Gastroenterol Nutr. 29(5): 563-70, 1999. Tissue Distribution Evidence: GLUT5 mRNA is expressed at highest levels in small intestine and testis and at much lower levels in kidney, skeletal muscle, and adipose tissue. (Northern blotting) Burant, C. F.; Takeda, J.; Brot-Laroche, E.; Bell, G. I.; Davidson, N. O. Fructose transporter in human spermatozoa and small intestine is GLUT5. J. Biol. Chem. 267: 14523-14526, 1992. Kayano, T.; Burant, C. F.; Fukumoto, H.; Gould, G. W.; Fan, Y. S.; Eddy, R. L.; Byers, M. G.; Shows, T. B.; Seino, S.; Bell, G. I. Human facilitative glucose transporters: isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6). J. Biol. Chem. 265: 13276-13282, 1990.
Tissues:High in small intestine and testis; low in kidney, skeletal muscle, and adipose tissue
Type:protein-coding
Sets:0
PharmGKB ID:PA35880
HPRD ID:00690
Substrates:Fructose, 2-deoxyglucose, D-glucose
Trivial Names:GLUT5, GLUT-5
Transcripts:NM_003039.2 [Chr.1(-): 9097005-9129887 GRCh37]
NM_001135585.1 [Chr.1(-): 9101427-9129887 GRCh37]
XM_005263491.1 [Chr.1(-): 9097005-9131763 GRCh37]
XM_005263492.1 [Chr.1(-): 9097005-9109313 GRCh37]
ENST00000377414 [Chr.1(-): 9100139-9129663 GRCh37]
ENST00000377424 [Chr.1(-): 9095166-9129775 GRCh37]
ENST00000464985 [Chr.1(-): 9107670-9148502 GRCh37]
ENST00000473209 [Chr.1(-): 9117557-9129910 GRCh37]
ENST00000474145 [Chr.1(-): 9101844-9132324 GRCh37]
ENST00000479813 [Chr.1(-): 9101844-9133181 GRCh37]
ENST00000484798 [Chr.1(-): 9101844-9131786 GRCh37]
ENST00000486632 [Chr.1(-): 9101844-9148537 GRCh37]
ENST00000487492 [Chr.1(-): 9098490-9099954 GRCh37]
ENST00000487835 [Chr.1(-): 9101917-9148516 GRCh37]
ENST00000535586 [Chr.1(-): 9097457-9129604 GRCh37]
ENST00000536305 [Chr.1(-): 9097173-9109319 GRCh37]
Annotation History:View Events (18)

GTEx Expression by Gene and Transcript

The heat map summarizes relative expression by tissue type at two levels of tissue detail, e.g., 'Brain' and 'Brain - Amygdala'. Choose among four calculated expression values, including mean and median RPKM values, and quantile normalized (QN) distributions of these values. (Note that differences between some distributions are subtle.) The coloring is relative to the mean of all displayed values. All values are log base 2. (See also PMT GTEx Expression Plotting.) Click on a transcript or tissue to resort the data.

Tissues:
Expression values:
No expression data exists for SLC2A5.

Variant Data

View all PMT variants for SLC2A5 on UCSC Genome Browser
Showing SNP features for transcript:   
1000 Genomes  

20141104 phase 3 variant call set of the 20130502 sequence freeze and alignments for SNPs and short indels (indels > 255 and structural variants are not included here). This variant set contains 2504 individuals from 26 populations (mouse over population column heading for population sizes).
Showing gene variants in regions defined by NCBI RefSeq exons, putative promoter, and PMT resequencing assays.
Note: Frequencies are calculated directly from reported genotypes and may vary from consensus frequencies reported by the 1000 Genomes project, which relied on additional data and the GATK tool Variant Quality Score Recalibrator.
dbSNP build 142.
Array availability: I - found on Illumina Human1M-Duo BeadChip (2011-04-21)  A - found on Affymetrix Genome-Wide SNP Array 6.0 (2011-06-21)  
Download the SNP table data as a tab-delimited file.

Transmembrane prediction:

Non-synonymous amino acid changes shown in red, indels (insertions and deletions) in blue, and synonymous changes in green. Exon(s) indicated by black outlines.