| Common Name: | GLUT8 |
| HGNC Symbol: | SLC2A8 |
| HGNC Description: | solute carrier family 2, (facilitated glucose transporter) member 8 |
| HGNC ID: | 13812 |
| Chromosome: | Chr.9(+): 129199286-129209988 |
| Location: | 9q33.3 |
| OMIM: | 605245 |
| OMIM Phenotype: | None |
| Accessions: | BC019043 |
| Nucleotide RefSeq: | NM_014580 |
| Protein RefSeq: | NP_055395 |
| Entrez: | 29988 |
| Isoforms: | 1 |
| Evidence: | Substrate In Vitro Evidence: Hexose, glucose (xenopus oocyte) Ibberson, M.; Uldry, M.; Thorens, B. GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues. J. Biol. Chem. 275: 4607-4612, 2000. COS-7 cells transfected with GLUT8 cDNA expressed a 42-kDa protein exhibiting specific, glucose-inhibitable cytochalasin B binding and reconstitutable glucose transport activity. Doege, H.; Schurmann, A.; Bahrenberg, G.; Brauers, A.; Joost, H. G. GLUT8, a novel member of the sugar transport facilitator family with glucose transport activity. J. Biol. Chem. 275: 16275-16280, 2000. Presence of this transporter may be necessary for successful blastocyst development, fuel metabolism, and subsequent implantation. Carayannopoulos, M. O.; Chi, M. M.-Y.; Cui, Y.; Pingsterhaus, J. M.; McKnight, R. A.; Mueckler, M.; Devaskar, S. U.; Moley, K. H. GLUT8 is a glucose transporter responsible for insulin-stimulated glucose uptake in the blastocyst. Proc. Nat. Acad. Sci. 97: 7313-7318, 2000. Substrate In Vivo Evidence: GLUT8 is intimately linked to glucose homeostasis Gorovits N, Cui L, Busik JV, Ranalletta M, Hauguel de-Mouzon S, Charron MJ. Regulation of hepatic GLUT8 expression in normal and diabetic models. Endocrinology 144(5):1703-11, 2003 Tissue Distribution Evidence: In human tissues, a 2.4-kilobase pair transcript was predominantly found in testis, but not in testicular carcinoma. Lower amounts of the mRNA were detected in most other tissues including skeletal muscle, heart, small intestine, and brain. (Northern blotting) Doege, H.; Schurmann, A.; Bahrenberg, G.; Brauers, A.; Joost, H. G. GLUT8, a novel member of the sugar transport facilitator family with glucose transport activity. J. Biol. Chem. 275: 16275-16280, 2000. |
| Tissues: | predominantly in testis; low in most other tissues including skeletal muscle, heart, small intestine, and brain |
| Type: | protein coding |
| Sets: | 0 |
| PharmGKB ID: | PA37813 |
| HPRD ID: | 05580 |
| Substrates: | Hexose, glucose |
| Trivial Names: | GLUT8, GLUTX1 |
| Transcripts: | NM_014580 [Chr.9(+): 129199286-129209998] |
View on UCSC Genome Browser or Ensembl Genome Browser
Transmembrane prediction:
Non-synonymous amino acid changes shown in red, indels (insertions and deletions) in blue, and synonymous changes in green. Exon(s) indicated by black outlines.