UCSF Pharmacogenetics of Membrane Transporters
Gene View
Common Name:ZNT3
HGNC Symbol:SLC30A3
HGNC Description:solute carrier family 30 (zinc transporter), member 3
HGNC ID:11014
Superfamily:SLC
Chromosome:Chr.2(-): 27477440-27501093 GRCh37
Location:2p23.3
OMIM:602878
OMIM Phenotype:None
Accessions:AL043136,BC028358
Nucleotide RefSeq:NM_003459
Protein RefSeq:NP_003450
Entrez:7781
Ensembl:ENSG00000115194
Isoforms:6
Evidence:Substrate In Vitro Evidence: Zinc in endosomal vesicles (mouse ZNT3) Palmiter et al 1996, PNAS, Vol 93, p.14934-14939 Substrate In Vivo Evidence: Low expression of ZNT3 accelerates brain aging in rat Saito et al 2000, Biochem Biophys Res Comm, Vol 279 (2), p.505-511 ZNT3 knockout mouse appears phenotypically normal, but has greatly reduded vesicular zinc in the brains of ZNT3 knockouts Cole et al 1999, PNAS, Vol 96 (4), p. 1716-1721 Tissue Distribution Evidence: Brain and testis by Northern Blot in mouse Palmiter et al 1996, PNAS, Vol 93, p.14934-14939
Tissues:glutamatergic neurons
Type:protein-coding
Sets:0
PharmGKB ID:PA35884
HPRD ID:11924
Substrates:Zinc
Trivial Names:ZNT3
Transcripts:NM_003459.4 [Chr.2(-): 27477440-27485960 GRCh37]
XM_005264550.1 [Chr.2(-): 27477440-27501093 GRCh37]
XM_005264549.1 [Chr.2(-): 27477440-27499014 GRCh37]
XM_005264548.1 [Chr.2(-): 27477440-27498289 GRCh37]
XM_005264551.1 [Chr.2(-): 27477440-27498288 GRCh37]
XM_005264547.1 [Chr.2(-): 27477440-27485956 GRCh37]
ENST00000233535 [Chr.2(-): 27477440-27486127 GRCh37]
ENST00000424577 [Chr.2(-): 27480774-27498209 GRCh37]
ENST00000426569 [Chr.2(-): 27480908-27498213 GRCh37]
ENST00000426924 [Chr.2(-): 27480070-27498685 GRCh37]
ENST00000432351 [Chr.2(-): 27479672-27487004 GRCh37]
ENST00000445870 [Chr.2(-): 27478254-27485739 GRCh37]
ENST00000447008 [Chr.2(-): 27477965-27498188 GRCh37]
ENST00000450118 [Chr.2(-): 27480872-27485028 GRCh37]
ENST00000482990 [Chr.2(-): 27476715-27480688 GRCh37]
ENST00000486309 [Chr.2(-): 27480865-27481912 GRCh37]
ENST00000497341 [Chr.2(-): 27476552-27481451 GRCh37]
Annotation History:View Events (42)

GTEx Expression by Gene and Transcript

The heat map summarizes relative expression by tissue type at two levels of tissue detail, e.g., 'Brain' and 'Brain - Amygdala'. Choose among four calculated expression values, including mean and median RPKM values, and quantile normalized (QN) distributions of these values. (Note that differences between some distributions are subtle.) The coloring is relative to the mean of all displayed values. All values are log base 2. (See also PMT GTEx Expression Plotting.) Click on a transcript or tissue to resort the data.

Tissues:
Expression values:
No expression data exists for SLC30A3.

Variant Data

View all PMT variants for SLC30A3 on UCSC Genome Browser
Showing SNP features for transcript:   
1000 Genomes  

20141104 phase 3 variant call set of the 20130502 sequence freeze and alignments for SNPs and short indels (indels > 255 and structural variants are not included here). This variant set contains 2504 individuals from 26 populations (mouse over population column heading for population sizes).
Showing gene variants in regions defined by NCBI RefSeq exons, putative promoter, and PMT resequencing assays.
Note: Frequencies are calculated directly from reported genotypes and may vary from consensus frequencies reported by the 1000 Genomes project, which relied on additional data and the GATK tool Variant Quality Score Recalibrator.
dbSNP build 142.
Array availability: I - found on Illumina Human1M-Duo BeadChip (2011-04-21)  A - found on Affymetrix Genome-Wide SNP Array 6.0 (2011-06-21)  
Download the SNP table data as a tab-delimited file.

Transmembrane prediction:

Non-synonymous amino acid changes shown in red, indels (insertions and deletions) in blue, and synonymous changes in green. Exon(s) indicated by black outlines.