UCSF Pharmacogenetics of Membrane Transporters
Gene View
Common Name:ZNT6
HGNC Symbol:SLC30A6
HGNC Description:solute carrier family 30 (zinc transporter), member 6
HGNC ID:19305
Superfamily:SLC
Chromosome:Chr.2(+): 32390910-32449181 GRCh37
Location:2p22.3
OMIM:611148
OMIM Phenotype:None
Accessions:AK055663
Nucleotide RefSeq:NM_017964
Protein RefSeq:NP_060434
Entrez:55676
Ensembl:ENSG00000152683
Isoforms:5
Evidence:Substrate In Vitro Evidence: ZNT6 appears to transport zinc out of the cytoplasm (yeast experiments) Huang et al 2002, JBC, Vol 277 (29), p. 26389-26395 Tissue Distribution Evidence: Brain, kidney intestine in mice by Western Blot, showed a wider tissue distribution with a Northern Blot Huang et al 2002, JBC, Vol 277 (29), p. 26389-26395 ZNT6 has some Golgi localization (immunoflurescence microscopy) Huang et al 2002, JBC, Vol 277 (29), p. 26389-26395
Tissues:widespread (by mRNA analysis in rodents)
Type:protein-coding
Sets:0
PharmGKB ID:PA134923067
HPRD ID:15368
Substrates:Zinc (by association)
Trivial Names:ZNT6, MST103, MSTP103
Transcripts:NM_017964.3 [Chr.2(+): 32390910-32449181 GRCh37]
NM_001193513.1 [Chr.2(+): 32390910-32449181 GRCh37]
NM_001193514.1 [Chr.2(+): 32390910-32449181 GRCh37]
NM_001193515.1 [Chr.2(+): 32390910-32449181 GRCh37]
XM_005264417.1 [Chr.2(+): 32390933-32449168 GRCh37]
ENST00000282587 [Chr.2(+): 32390933-32449448 GRCh37]
ENST00000357055 [Chr.2(+): 32390933-32446735 GRCh37]
ENST00000379343 [Chr.2(+): 32390933-32446593 GRCh37]
ENST00000406369 [Chr.2(+): 32390938-32449168 GRCh37]
ENST00000435660 [Chr.2(+): 32390933-32446809 GRCh37]
ENST00000440718 [Chr.2(+): 32390933-32422853 GRCh37]
ENST00000449777 [Chr.2(+): 32390933-32446809 GRCh37]
ENST00000454324 [Chr.2(+): 32390933-32446735 GRCh37]
ENST00000457724 [Chr.2(+): 32390951-32418020 GRCh37]
ENST00000538303 [Chr.2(+): 32390933-32446216 GRCh37]

GTEx Expression by Gene and Transcript

The heat map summarizes relative expression by tissue type at two levels of tissue detail, e.g., 'Brain' and 'Brain - Amygdala'. Choose among four calculated expression values, including mean and median RPKM values, and quantile normalized (QN) distributions of these values. (Note that differences between some distributions are subtle.) The coloring is relative to the mean of all displayed values. All values are log base 2. (See also PMT GTEx Expression Plotting.) Click on a transcript or tissue to resort the data.

Tissues:
Expression values:
No expression data exists for SLC30A6.

Variant Data

View all PMT variants for SLC30A6 on UCSC Genome Browser
Showing SNP features for transcript:   
1000 Genomes  

20141104 phase 3 variant call set of the 20130502 sequence freeze and alignments for SNPs and short indels (indels > 255 and structural variants are not included here). This variant set contains 2504 individuals from 26 populations (mouse over population column heading for population sizes).
Showing gene variants in regions defined by NCBI RefSeq exons, putative promoter, and PMT resequencing assays.
Note: Frequencies are calculated directly from reported genotypes and may vary from consensus frequencies reported by the 1000 Genomes project, which relied on additional data and the GATK tool Variant Quality Score Recalibrator.
dbSNP build 142.
Array availability: I - found on Illumina Human1M-Duo BeadChip (2011-04-21)  A - found on Affymetrix Genome-Wide SNP Array 6.0 (2011-06-21)  
Download the SNP table data as a tab-delimited file.

Transmembrane prediction:

Non-synonymous amino acid changes shown in red, indels (insertions and deletions) in blue, and synonymous changes in green. Exon(s) indicated by black outlines.