UCSF Pharmacogenetics of Membrane Transporters
Gene View
Common Name:ZNT7
HGNC Symbol:SLC30A7
HGNC Description:solute carrier family 30 (zinc transporter), member 7
HGNC ID:19306
Superfamily:SLC
Chromosome:Chr.1(+): 101361632-101552821 GRCh37
Location:1p21.2
OMIM:611149
OMIM Phenotype:None
Accessions:BC064692
Nucleotide RefSeq:NM_133496
Protein RefSeq:NP_598003
Entrez:148867
Ensembl:ENSG00000162695
Isoforms:4
Evidence:Substrate In Vitro Evidence: Zinc, ZNT7 causes zinc to accumulate in the Golgi apparatus in CHO cells Kirschke et al 2003, JBC, Vol 278 (6), p.4096-4102 Tissue Distribution Evidence: Liver, kidney, spleen, heart, brain, small intestine, and lung in mouse by Northern Blot, but Western Blot detected no expression in brain, heart, liver, or kidney Kirschke et al 2003, JBC, Vol 278 (6), p.4096-4102 ZNT7 has some Golgi localization (immunofluorescence microscopy) Kirschke et al 2003, JBC, Vol 278 (6), p.4096-4102
Tissues:widespread (by mRNA analysis in rodents)
Type:protein-coding
Sets:0
PharmGKB ID:PA134891595
HPRD ID:15369
Substrates:Zinc
Trivial Names:ZNT7, ZnT-7, ZnTL2
Transcripts:NM_133496.4 [Chr.1(+): 101361634-101447311 GRCh37]
NM_001144884.1 [Chr.1(+): 101361632-101447311 GRCh37]
XM_005270504.1 [Chr.1(+): 101361634-101552821 GRCh37]
XM_005270503.1 [Chr.1(+): 101361634-101461195 GRCh37]
ENST00000357650 [Chr.1(+): 101361810-101440554 GRCh37]
ENST00000370111 [Chr.1(+): 101427384-101438214 GRCh37]
ENST00000370112 [Chr.1(+): 101361632-101447309 GRCh37]
Annotation History:View Events (18)

GTEx Expression by Gene and Transcript

The heat map summarizes relative expression by tissue type at two levels of tissue detail, e.g., 'Brain' and 'Brain - Amygdala'. Choose among four calculated expression values, including mean and median RPKM values, and quantile normalized (QN) distributions of these values. (Note that differences between some distributions are subtle.) The coloring is relative to the mean of all displayed values. All values are log base 2. (See also PMT GTEx Expression Plotting.) Click on a transcript or tissue to resort the data.

Tissues:
Expression values:
No expression data exists for SLC30A7.

Variant Data

View all PMT variants for SLC30A7 on UCSC Genome Browser
Showing SNP features for transcript:   
1000 Genomes  

20141104 phase 3 variant call set of the 20130502 sequence freeze and alignments for SNPs and short indels (indels > 255 and structural variants are not included here). This variant set contains 2504 individuals from 26 populations (mouse over population column heading for population sizes).
Showing gene variants in regions defined by NCBI RefSeq exons, putative promoter, and PMT resequencing assays.
Note: Frequencies are calculated directly from reported genotypes and may vary from consensus frequencies reported by the 1000 Genomes project, which relied on additional data and the GATK tool Variant Quality Score Recalibrator.
dbSNP build 142.
Array availability: I - found on Illumina Human1M-Duo BeadChip (2011-04-21)  A - found on Affymetrix Genome-Wide SNP Array 6.0 (2011-06-21)  
Download the SNP table data as a tab-delimited file.

Transmembrane prediction:

Non-synonymous amino acid changes shown in red, indels (insertions and deletions) in blue, and synonymous changes in green. Exon(s) indicated by black outlines.