UCSF Pharmacogenetics of Membrane Transporters
Gene View
Common Name:G3PP
HGNC Symbol:SLC37A1
HGNC Description:solute carrier family 37 (glucose-6-phosphate transporter), member 1
HGNC ID:11024
Superfamily:SLC
Chromosome:Chr.21(+): 43919742-44001550 GRCh37
Location:21q22.3
OMIM:608094
OMIM Phenotype:None
Accessions:AJ269529,AL355683,AW466890,BI912541
Nucleotide RefSeq:NM_018964
Protein RefSeq:NP_061837
Entrez:54020
Ensembl:ENSG00000160190
Isoforms:5
Evidence:Substrate In Vitro Evidence: Based on homology to the bacterial glycerol-3-phosphate transporter, SLC37A1 is believed to be an inorganic phosphate-dependent antiport specific for glycerol-3-phosphate, although this has yet to be conclusively shown. Bartoloni et al 2000, Genomics, Vol 70 (2), p.190-200 Bartoloni et al 2003, Pflugers Arch Tissue Distribution Evidence: Found in most tissues tested by Northern Blot. Highest expression was found in fetal tissues, and adult liver, kidney, and spleen by dot blot and RT-PCR. Bartoloni et al 2000, Genomics, Vol 70 (2), p.190-200
Tissues:adult bone marrow, colon, small intestine, kidney, liver, fetal liver, fetal spleen
Type:protein-coding
Sets:0
PharmGKB ID:PA35892
HPRD ID:10479
Substrates:glycerol-3-phosphate
Trivial Names:G3PP
Transcripts:NM_018964.3 [Chr.21(+): 43919742-44001550 GRCh37]
XM_005261141.1 [Chr.21(+): 43934273-44001546 GRCh37]
XM_005261139.1 [Chr.21(+): 43934273-43997751 GRCh37]
XM_005261140.1 [Chr.21(+): 43934276-43997751 GRCh37]
XM_005261142.1 [Chr.21(+): 43945911-43997751 GRCh37]
ENST00000352133 [Chr.21(+): 43934024-44001550 GRCh37]
ENST00000398341 [Chr.21(+): 43919742-44001550 GRCh37]
ENST00000398343 [Chr.21(+): 43934634-43938620 GRCh37]
ENST00000419522 [Chr.21(+): 43916128-43938620 GRCh37]
ENST00000454800 [Chr.21(+): 43916118-43918313 GRCh37]
ENST00000471277 [Chr.21(+): 43934002-43946148 GRCh37]
ENST00000484887 [Chr.21(+): 43919817-43923084 GRCh37]
ENST00000487951 [Chr.21(+): 43963627-43967827 GRCh37]
ENST00000496416 [Chr.21(+): 43985937-43996057 GRCh37]
Annotation History:View Events (35)

GTEx Expression by Gene and Transcript

The heat map summarizes relative expression by tissue type at two levels of tissue detail, e.g., 'Brain' and 'Brain - Amygdala'. Choose among four calculated expression values, including mean and median RPKM values, and quantile normalized (QN) distributions of these values. (Note that differences between some distributions are subtle.) The coloring is relative to the mean of all displayed values. All values are log base 2. (See also PMT GTEx Expression Plotting.) Click on a transcript or tissue to resort the data.

Tissues:
Expression values:
No expression data exists for SLC37A1.

Variant Data

View all PMT variants for SLC37A1 on UCSC Genome Browser
Showing SNP features for transcript:   
1000 Genomes  

20141104 phase 3 variant call set of the 20130502 sequence freeze and alignments for SNPs and short indels (indels > 255 and structural variants are not included here). This variant set contains 2504 individuals from 26 populations (mouse over population column heading for population sizes).
Showing gene variants in regions defined by NCBI RefSeq exons, putative promoter, and PMT resequencing assays.
Note: Frequencies are calculated directly from reported genotypes and may vary from consensus frequencies reported by the 1000 Genomes project, which relied on additional data and the GATK tool Variant Quality Score Recalibrator.
dbSNP build 142.
Array availability: I - found on Illumina Human1M-Duo BeadChip (2011-04-21)  A - found on Affymetrix Genome-Wide SNP Array 6.0 (2011-06-21)  
Download the SNP table data as a tab-delimited file.

Transmembrane prediction: TOPO2 image is not available.