UCSF Pharmacogenetics of Membrane Transporters
Gene View
Common Name:OATPE
HGNC Symbol:SLCO4A1
HGNC Description:solute carrier organic anion transporter family, member 4A1
HGNC ID:10953
Superfamily:SLC
Chromosome:Chr.20(+): 61273795-61317137 GRCh37
Location:20q13.33
OMIM:612436
OMIM Phenotype:None
Accessions:NM_016354
Nucleotide RefSeq:NM_016354
Protein RefSeq:NP_057438
Entrez:28231
Ensembl:ENSG00000101187
Isoforms:2
Evidence:Substrate In Vitro Evidence: Bile salts: taurocholate BBA18 X oocytes Hormones and their conjugates: estradiol-17?-glucuronide BBA4 HEK293 estrone-3-sulfate BBA4 HEK293 T3 BBA18 X oocytes T4 BBA18 X oocytes Eicosanoids: prostaglandine E2 BBA4 HEK293 Tissue Distribution Evidence: ubiqitously BBA4 RT-PCR
Tissues:ubiqitously
Type:protein-coding
Sets:V
PharmGKB ID:PA35838
HPRD ID:11582
Substrates:taurocholate,estradiol-17b-glucuronide, estrone-3-sulfate, T3, T4, prostaglandine E2
Trivial Names:POAT, OATP1, OATPE, OATP-E, OATP4A1, OATPRP1, SLC21A12
Transcripts:NM_016354.3 [Chr.20(+): 61273797-61303647 GRCh37]
XM_005260203.1 [Chr.20(+): 61273795-61317137 GRCh37]
ENST00000217159 [Chr.20(+): 61273797-61303647 GRCh37]
ENST00000370507 [Chr.20(+): 61287711-61303645 GRCh37]
ENST00000451793 [Chr.20(+): 61299165-61303645 GRCh37]
ENST00000466818 [Chr.20(+): 61299832-61317137 GRCh37]
ENST00000466961 [Chr.20(+): 61299093-61303506 GRCh37]
ENST00000470412 [Chr.20(+): 61297767-61301574 GRCh37]
ENST00000495889 [Chr.20(+): 61298830-61303959 GRCh37]
ENST00000497209 [Chr.20(+): 61273872-61303645 GRCh37]
ENST00000497919 [Chr.20(+): 61299771-61301470 GRCh37]
Annotation History:View Events (11)

GTEx Expression by Gene and Transcript

The heat map summarizes relative expression by tissue type at two levels of tissue detail, e.g., 'Brain' and 'Brain - Amygdala'. Choose among four calculated expression values, including mean and median RPKM values, and quantile normalized (QN) distributions of these values. (Note that differences between some distributions are subtle.) The coloring is relative to the mean of all displayed values. All values are log base 2. (See also PMT GTEx Expression Plotting.) Click on a transcript or tissue to resort the data.

Tissues:
Expression values:
No expression data exists for SLCO4A1.

Variant Data

View all PMT variants for SLCO4A1 on UCSC Genome Browser
Showing SNP features for transcript:   
1000 Genomes  

20141104 phase 3 variant call set of the 20130502 sequence freeze and alignments for SNPs and short indels (indels > 255 and structural variants are not included here). This variant set contains 2504 individuals from 26 populations (mouse over population column heading for population sizes).
Showing gene variants in regions defined by NCBI RefSeq exons, putative promoter, and PMT resequencing assays.
Note: Frequencies are calculated directly from reported genotypes and may vary from consensus frequencies reported by the 1000 Genomes project, which relied on additional data and the GATK tool Variant Quality Score Recalibrator.
dbSNP build 142.
Array availability: I - found on Illumina Human1M-Duo BeadChip (2011-04-21)  A - found on Affymetrix Genome-Wide SNP Array 6.0 (2011-06-21)  
Download the SNP table data as a tab-delimited file.

Transmembrane prediction:

Non-synonymous amino acid changes shown in red, indels (insertions and deletions) in blue, and synonymous changes in green. Exon(s) indicated by black outlines.