UCSF Pharmacogenetics of Membrane Transporters
Snp Publications
  1. Gregers J, Gréen H, Christensen IJ, Dalhoff K, Schroeder H, Carlsen N, Rosthoej S, Lausen B, Schmiegelow K, Peterson C. Polymorphisms in the ABCB1 gene and effect on outcome and toxicity in childhood acute lymphoblastic leukemia. Pharmacogenomics J. 2015 Jan 13. PMID: 25582575.
  2. Jakobsen Falk I, Fyrberg A, Paul E, Nahi H, Hermanson M, Rosenquist R, Höglund M, Palmqvist L, Stockelberg D, Wei Y, Gréen H, Lotfi K. Impact of ABCB1 single nucleotide polymorphisms 1236C>T and 2677G>T on overall survival in FLT3 wild-type de novo AML patients with normal karyotype. Br J Haematol. 2014 Aug 23. PMID: 25155901.
  3. Dizdarevic S, Aplin M, Newport MJ, Ryan N, Holt S, Goubet S, Goldberg L, Miles KA, Peters AM. Old tracer for a new purpose: potential role for 99mTc-2-methoxyisobutylisonitrile (99mTc-MIBI) in renal transplant care. Nucl Med Commun. 2014 Jul 14. PMID: 25025147.
  4. Vasilopoulos Y, Sarri C, Zafiriou E, Patsatsi A, Stamatis C, Ntoumou E, Fassos I, Tsalta A, Karra A, Roussaki-Schulze A, Sotiriadis D, Mamuris Z, Sarafidou T. A pharmacogenetic study of ABCB1 polymorphisms and cyclosporine treatment response in patients with psoriasis in the Greek population. Pharmacogenomics J. 2014 Jun 3. PMID: 24889923.
  5. PLOS ONE Staff. Correction: ABCB1 1199G>A Genetic Polymorphism (Rs2229109) Influences the Intracellular Accumulation of Tacrolimus in HEK293 and K562 Recombinant Cell Lines. PLoS One. 2014;9(10):e112519. PMID: 25360816.
  6. Escalante-Santiago D, Feria-Romero IA, Ribas-Aparicio RM, Rayo-Mares D, Fagiolino P, Vázquez M, Escamilla-Núñez C, Grijalva-Otero I, López-García MA, Orozco-Suárez S. MDR-1 and MRP2 Gene Polymorphisms in Mexican Epileptic Pediatric Patients with Complex Partial Seizures. Front Neurol. 2014;5184. PMID: 25346718.
  7. Dessilly G, Elens L, Panin N, Capron A, Decottignies A, Demoulin JB, Haufroid V. ABCB1 1199G>A Genetic Polymorphism (Rs2229109) Influences the Intracellular Accumulation of Tacrolimus in HEK293 and K562 Recombinant Cell Lines. PLoS One. 2014;9(3):e91555. PMID: 24621983.
  8. Bosó V, Herrero MJ, Buso E, Galán J, Almenar L, Sánchez-Lázaro I, Sánchez-Plumed J, Bea S, Prieto M, García M, Pastor A, Sole A, Poveda JL, Aliño SF. Genotype and Allele Frequencies of Drug-Metabolizing Enzymes and Drug Transporter Genes Affecting Immunosuppressants in the Spanish White Population. Ther Drug Monit. 2013 Nov 13. PMID: 24232128.
  9. Skoglund K, Moreno SB, Baytar M, Jönsson JI, Gréen H. ABCB1 haplotypes do not influence transport or efficacy of tyrosine kinase inhibitors in vitro. Pharmgenomics Pers Med. 2013 Aug 20;663-72. PMID: 24019750.
  10. Rabasseda X. A report from the 7th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention (June 30-July 3, 2013 - Kuala Lumpur, Malaysia). Drugs Today (Barc). 2013 Aug;49(8):509-17. PMID: 23977668.
  11. Boiso Moreno S, Zackrisson AL, Jakobsen Falk I, Karlsson L, Carlsson B, Tillmar A, Kugelberg FC, Ahlner J, Hägg S, Gréen H. ABCB1 gene polymorphisms are associated with suicide in forensic autopsies. Pharmacogenet Genomics. 2013 Jun 29. PMID: 23820292.
  12. Mostafa-Hedeab G, Saber-Ayad MM, Latif IA, Elkashab SO, Elshaboney TH, Mostafa MI, El-Shafy SA, Zaki MM. Functional G1199A ABCB1 Polymorphism May Have an Effect on Cyclosporine Blood Concentration in Renal Transplanted Patients. J Clin Pharmacol. 2013 May 30. PMID: 23720091.
  13. Karlsson L, Green H, Zackrisson AL, Bengtsson F, Jakobsen Falk I, Carlsson B, Ahlner J, Kugelberg FC. ABCB1 gene polymorphisms are associated with fatal intoxications involving venlafaxine but not citalopram. Int J Legal Med. 2013 Mar 21. PMID: 23515680.
  14. Dogruer D, Tug E, Bes C, Soy M. Lack of an effect of CYP3A4 and MDR1 gene polymorphisms on colchicine pharmacogenetics in the treatment of Familial Mediterranean fever. Genet Mol Res. 2013 Jan 24;12(AOP). PMID: 23408444.
  15. De Meyer M, Haufroid V, Elens L, Fusaro F, Patrono D, De Pauw L, Kanaan N, Goffin E, Mourad M. Donor age and ABCB1 1199G>A genetic polymorphism are independent factors affecting long-term renal function after kidney transplantation. J Surg Res. 2012 Jul 20. PMID: 22835948.
  16. Barratt DT, Coller JK, Hallinan R, Byrne A, White JM, Foster DJ, Somogyi AA. ABCB1 haplotype and OPRM1 118A > G genotype interaction in methadone maintenance treatment pharmacogenetics. Pharmgenomics Pers Med. 2012;553-62. PMID: 23226062.
  17. Jordán de Luna C, Herrero Cervera MJ, Sánchez Lázaro I, Almenar Bonet L, Poveda Andrés JL, Aliño Pellicer SF. Pharmacogenetic Study of ABCB1 and CYP3A5 Genes During the First Year Following Heart Transplantation Regarding Tacrolimus or Cyclosporine Levels. Transplant Proc. 2011 Jul-Aug;43(6):2241-3. PMID: 21839244.
  18. Sainz J, Rudolph A, Hein R, Hoffmeister M, Buch S, von Schönfels W, Hampe J, Schafmayer C, Völzke H, Frank B, Brenner H, Försti A, Hemminki K, Chang-Claude J. Association of genetic polymorphisms in ESR2, HSD17B1, ABCB1, and SHBG genes with colorectal cancer risk. Endocr Relat Cancer. 2011;18(2):265-276. PMID: 21317201.
  19. Gréen H, Falk IJ, Lotfi K, Paul E, Hermansson M, Rosenquist R, Paul C, Nahi H. Association of ABCB1 polymorphisms with survival and in vitro cytotoxicty in de novo acute myeloid leukemia with normal karyotype. Pharmacogenomics J. 2010 Oct 12. PMID: 20938465.
  20. Capron A, Mourad M, De Meyer M, De Pauw L, Eddour DC, Latinne D, Elens L, Haufroid V, Wallemacq P. CYP3A5 and ABCB1 polymorphisms influence tacrolimus concentrations in peripheral blood mononuclear cells after renal transplantation. Pharmacogenomics. 2010 May;11(5):703-14. PMID: 20415563.
  21. Jeannesson E, Siest G, Bastien B, Albertini L, Aslanidis C, Schmitz G, Visvikis-Siest S. Association of ABCB1 gene polymorphisms with plasma lipid and apolipoprotein concentrations in the Stanislas Cohort. Clin Chim Acta. 2009 Mar 10. PMID: 19285054.
  22. Woodahl EL, Crouthamel MH, Bui T, Shen DD, Ho RJ. MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Cancer Chemother Pharmacol. 2009 Jan 4. PMID: 19123050.
  23. Yang Z, Wu D, Bui T, Ho RJ. A novel human multidrug resistance gene MDR1 variant G571A (G191R) modulates cancer drug resistance and efflux transport. J Pharmacol Exp Ther. 2008 Nov;327(2):474-81. PMID: 18723777.
  24. Woodahl EL, Hingorani SR, Wang J, Guthrie KA, McDonald GB, Batchelder A, Li M, Schoch HG, McCune JS. Pharmacogenomic associations in ABCB1 and CYP3A5 with acute kidney injury and chronic kidney disease after myeloablative hematopoietic cell transplantation. Pharmacogenomics J. 2008 Aug;8(4):248-55. PMID: 17700595.
  25. Gréen H, Söderkvist P, Rosenberg P, Horvath G, Peterson C. ABCB1 G1199A polymorphism and ovarian cancer response to paclitaxel. J Pharm Sci. 2008 Jun;97(6):2045-8. PMID: 17828752.
  26. Xu P, Jiang ZP, Zhang BK, Tu JY, Li HD. Impact of MDR1 haplotypes derived from C1236T, G2677T/A and C3435T on the pharmacokinetics of single-dose oral digoxin in healthy Chinese volunteers. Pharmacology. 2008;82(3):221-7. PMID: 18810246.
  27. Seedhouse CH, Grundy M, White P, Li Y, Fisher J, Yakunina D, Moorman AV, Hoy T, Russell N, Burnett A, Pallis M, National Cancer Research Network. Sequential influences of leukemia-specific and genetic factors on p-glycoprotein expression in blasts from 817 patients entered into the National Cancer Research Network acute myeloid leukemia 14 and 15 trials. Clin Cancer Res. 2007 Dec 1;13(23):7059-66. PMID: 18056183.
  28. Elens L, Capron A, Kerckhove VV, Lerut J, Mourad M, Lison D, Wallemacq P, Haufroid V. 1199G>A and 2677G>T/A polymorphisms of ABCB1 independently affect tacrolimus concentration in hepatic tissue after liver transplantation. Pharmacogenet Genomics. 2007 Oct;17(10):873-83. PMID: 17885626.
  29. Jeannesson E, Albertini L, Siest G, Gomes AM, Ribeiro V, Aslanidis C, Schmitz G, Visvikis-Siest S. Determination of ABCB1 polymorphisms and haplotypes frequencies in a French population. Fundam Clin Pharmacol. 2007 Aug;21(4):411-8. PMID: 17635180.
  30. Sakurai A, Onishi Y, Hirano H, Seigneuret M, Obanayama K, Kim G, Liew EL, Sakaeda T, Yoshiura K, Niikawa N, Sakurai M, Ishikawa T. Quantitative structure--activity relationship analysis and molecular dynamics simulation to functionally validate nonsynonymous polymorphisms of human ABC transporter ABCB1 (P-glycoprotein/MDR1). Biochemistry. 2007 Jul 3;46(26):7678-93. PMID: 17559192.
  31. Zhang WX, Chen B, Zhang W, Chen N, Yu ZC, Cai WM. Effect of MDR1 gene polymorphism on progression of end-stage renal disease. Acta Pharmacol Sin. 2007 Apr;28(4):579-83. PMID: 17376299.
  32. Nordgard SH, Ritchie MD, Jensrud SD, Motsinger AA, Alnaes GI, Lemmon G, Berg M, Geisler S, Moore JH, Lønning PE, Børresen-Dale AL, Kristensen VN. ABCB1 and GST polymorphisms associated with TP53 status in breast cancer. Pharmacogenet Genomics. 2007 Feb;17(2):127-36. PMID: 17301692.
  33. Crouthamel MH, Wu D, Yang Z, Ho RJ. A novel MDR1 G1199T variant alters drug resistance and efflux transport activity of P-glycoprotein in recombinant Hek cells. J Pharm Sci. 2006 Dec;95(12):2767-77. PMID: 16917872.
  34. Woodahl EL, Yang Z, Bui T, Shen DD, Ho RJ. MDR1 G1199A polymorphism alters permeability of HIV protease inhibitors across P-glycoprotein-expressing epithelial cells. AIDS. 2005 Oct 14;19(15):1617-25. PMID: 16184031.
  35. Woodahl EL, Yang Z, Bui T, Shen DD, Ho RJ. Multidrug resistance gene G1199A polymorphism alters efflux transport activity of P-glycoprotein. J Pharmacol Exp Ther. 2004 Sep;310(3):1199-207. PMID: 15100388.
  36. Kimchi-Sarfaty C, Gribar JJ, Gottesman MM. Functional characterization of coding polymorphisms in the human MDR1 gene using a vaccinia virus expression system. Mol Pharmacol. 2002 Jul;62(1):1-6. PMID: 12065748.
  37. Cascorbi I, Gerloff T, Johne A, Meisel C, Hoffmeyer S, Schwab M, Schaeffeler E, Eichelbaum M, Brinkmann U, Roots I. Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects. Clin Pharmacol Ther. 2001 Mar;69(3):169-74. PMID: 11240981.