UCSF Pharmacogenetics of Membrane Transporters
Snp Publications
PMT SNP UID:3876
  1. Singh AB, Bousman CA, Ng CH, Byron K, Berk M. Effects of persisting emotional impact from child abuse and norepinephrine transporter genetic variation on antidepressant efficacy in major depression: a pilot study. Clin Psychopharmacol Neurosci. 2015 Apr 30;13(1):53-61. PMID: 25912538.
  2. Kim YK, Hwang JA, Lee HJ, Yoon HK, Ko YH, Lee BH, Jung HY, Hahn SW, Na KS. Association between norepinephrine transporter gene (SLC6A2) polymorphisms and suicide in patients with major depressive disorder. J Affect Disord. 2014 Apr;158127-32. PMID: 24655776.
  3. Niitsu T, Fabbri C, Bentini F, Serretti A. Pharmacogenetics in major depression: a comprehensive meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry. 2013 May 31. PMID: 23733030.
  4. Zhao X, Huang Y, Ma H, Jin Q, Wang Y, Zhu G. Association between major depressive disorder and the norepinephrine transporter polymorphisms T-182C and G1287A: A meta-analysis. J Affect Disord. 2013 May 3. PMID: 23648227.
  5. Kim BN, Kim JW, Cummins TD, Bellgrove MA, Hawi Z, Hong SB, Yang YH, Kim HJ, Shin MS, Cho SC, Kim JH, Son JW, Shin YM, Chung US, Han DH. Norepinephrine Genes Predict Response Time Variability and Methylphenidate-Induced Changes in Neuropsychological Function in Attention Deficit Hyperactivity Disorder. J Clin Psychopharmacol. 2013 Apr 19. PMID: 23609393.
  6. Singh AB, Bousman CA, Ng CH, Byron K, Berk M. Psychomotor depressive symptoms may differentially respond to venlafaxine. Int Clin Psychopharmacol. 2013 Feb 25. PMID: 23442739.
  7. Li X, Sun N, Xu Y, Wang Y, Li S, Du Q, Peng J, Luo J, Zhang K. The norepinephrine transporter gene is associated with the retardation symptoms of major depressive disorder in the Han Chinese population. Neural Regen Res. 2012 Sep 5;7(25):1985-91. PMID: 25624829.
  8. Houston J, Zou W, Aris V, Fijal B, Chen P, Heinloth A, Martinez J. Evaluation of genetic models for response in a randomized clinical trial of duloxetine in major depressive disorder. Psychiatry Res. 2012 Jun 22. PMID: 22727709.
  9. Park S, Kim JW, Yang YH, Hong SB, Park MH, Kim BN, Shin MS, Yoo HJ, Cho SC. Possible effect of norepinephrine transporter polymorphisms on methylphenidate-induced changes in neuropsychological function in attention-deficit hyperactivity disorder. Behav Brain Funct. 2012 May 16;8(1):22. PMID: 22591463.
  10. Park MH, Kim JW, Yang YH, Hong SB, Park S, Kang H, Kim BN, Shin MS, Yoo HJ, Cho SC. Regional brain perfusion before and after treatment with methylphenidate may be associated with the G1287A polymorphism of the norepinephrine transporter gene in children with attention-deficit/hyperactivity disorder. Neurosci Lett. 2012 Mar 3. PMID: 22405810.
  11. Cho SC, Kim BN, Cummins TD, Kim JW, Bellgrove MA. Norepinephrine transporter -3081(A/T) and alpha-2A-adrenergic receptor MspI polymorphisms are associated with cardiovascular side effects of OROS-methylphenidate treatment. J Psychopharmacol. 2011 May 31. PMID: 21628343.
  12. Song DH, Jhung K, Song J, Cheon KA. The 1287 G/A polymorphism of the Norepinephrine Transporter gene (NET) is involved in Commission Errors in Korean children with Attention Deficit Hyperactivity Disorder. Behav Brain Funct. 2011 May 13;7(1):12. PMID: 21569456.
  13. Miguita K, Cordeiro Q, Shavitt RG, Miguel EC, Vallada H. Association study between genetic monoaminergic polymorphisms and OCD response to clomipramine treatment. Arq Neuropsiquiatr. 2011;69(2B):283-7. PMID: 21625751.
  14. Song J, Song DH, Jhung K, Cheon KA. Norepinephrine transporter gene (SLC6A2) is involved with methylphenidate response in Korean children with attention deficit hyperactivity disorder. Int Clin Psychopharmacol. 2010 Nov 30. PMID: 21127421.
  15. Kim BN, Kim JW, Hong SB, Cho SC, Shin MS, Yoo HJ. Possible association of norepinephrine transporter -3081(A/T) polymorphism with methylphenidate response in attention deficit hyperactivity disorder. Behav Brain Funct. 2010 Oct 7;6(1):57. PMID: 20929549.
  16. Lee SH, Kim SW, Lee MG, Yook KH, Greenhill LL, Frandin KN, Hong HJ. Lack of association between response of OROS-methylphenidate and norepinephrine transporter (SLC6A2) polymorphism in Korean ADHD. Psychiatry Res. 2010 Sep 20. PMID: 20863575.
  17. Shiroma PR, Geda YE, Mrazek DA. Pharmacogenomic implications of variants of monoaminergic-related genes in geriatric psychiatry. Pharmacogenomics. 2010 Sep;11(9):1305-30. PMID: 20860469.
  18. Dlugos AM, Hamidovic A, Palmer AA, de Wit H. Further evidence of association between amphetamine response and SLC6A2 gene variants. Psychopharmacology (Berl). 2009 Sep 2. PMID: 19727679.
  19. Xu Y, Li F, Huang X, Sun N, Zhang F, Liu P, Yang H, Luo J, Sun Y, Zhang K. The norepinephrine transporter gene modulates the relationship between urban/rural residency and major depressive disorder in a Chinese population. Psychiatry Res. 2009 Jun 27. PMID: 19564048.
  20. Min W, Li T, Ma X, Li Z, Yu T, Gao D, Zhang B, Yun Y, Sun X. Monoamine transporter gene polymorphisms affect susceptibility to depression and predict antidepressant response. Psychopharmacology (Berl). 2009 May 26. PMID: 19468717.
  21. Higuchi H, Takahashi H, Kamata M, Yoshida K. Influence of serotonergic/noradrenergic gene polymorphisms on nausea and sweating induced by milnacipran in the treatment of depression. Neuropsychiatr Dis Treat. 2009;5393-8. PMID: 19649213.
  22. Sun N, Xu Y, Wang Y, Duan H, Wang S, Ren Y, Peng J, Du Q, Shen Y, Xu Q, Zhang K. The combined effect of norepinephrine transporter gene and negative life events in major depression of Chinese Han population. J Neural Transm. 2008 Sep 9. PMID: 18779921.
  23. Méary A, Brousse G, Jamain S, Schmitt A, Szöke A, Schürhoff F, Gavaudan G, Lancon C, Macquin-Mavier I, Leboyer M, Llorca PM. Pharmacogenetic study of atypical antipsychotic drug response: involvement of the norepinephrine transporter gene. Am J Med Genet B Neuropsychiatr Genet. 2008 Jun 5;147B(4):491-4. PMID: 18085566.
  24. Cho SC, Kim JW, Kim BN, Hwang JW, Park M, Kim SA, Cho DY, Yoo HJ, Chung US, Son JW, Park TW. No evidence of an association between norepinephrine transporter gene polymorphisms and attention deficit hyperactivity disorder: a family-based and case-control association study in a Korean sample. Neuropsychobiology. 2008;57(3):131-8. PMID: 18552510.
  25. Retz W, Rösler M, Kissling C, Wiemann S, Hünnerkopf R, Coogan A, Thome J, Freitag C. Norepinephrine transporter and catecholamine-O-methyltransferase gene variants and attention-deficit/hyperactivity disorder symptoms in adults. J Neural Transm. 2008;115(2):323-9. PMID: 17994190.
  26. Huang SY, Lu RB, Ma KH, Shy MJ, Lin WW. Norepinephrine transporter polymorphisms T-182C and G1287A are not associated with alcohol dependence and its clinical subgroups. Drug Alcohol Depend. 2008 Jan 1;92(1-3):20-6. PMID: 17630229.
  27. Inoue K, Itoh K, Yoshida K, Higuchi H, Kamata M, Takahashi H, Shimizu T, Suzuki T. No association of the G1287A polymorphism in the norepinephrine transporter gene and susceptibility to major depressive disorder in a Japanese population. Biol Pharm Bull. 2007 Oct;30(10):1996-8. PMID: 17917281.
  28. Chang CC, Lu RB, Chen CL, Chu CM, Chang HA, Huang CC, Huang YL, Huang SY. Lack of association between the norepinephrine transporter gene and major depression in a Han Chinese population. J Psychiatry Neurosci. 2007 Mar;32(2):121-8. PMID: 17353941.
  29. Chang CC, Lu RB, Ma KH, Chang HA, Chen CL, Huang CC, Lin WW, Huang SY. Association study of the norepinephrine transporter gene polymorphisms and bipolar disorder in Han Chinese population. World J Biol Psychiatry. 2007;8(3):188-95. PMID: 17654409.
  30. Kim H, Lim SW, Kim S, Kim JW, Chang YH, Carroll BJ, Kim DK. Monoamine transporter gene polymorphisms and antidepressant response in koreans with late-life depression. JAMA. 2006 Oct 4;296(13):1609-18. PMID: 17018806.
  31. Rippel CA, Kobets AJ, Yoon DY, Williams PN, Shugart YY, Bridges DD, Vandenbergh DJ, Singer HS. Norepinephrine transporter polymorphisms in Tourette syndrome with and without attention deficit hyperactivity disorder: no evidence for significant association. Psychiatr Genet. 2006 Oct;16(5):179-80. PMID: 16969268.
  32. Kirchheiner J, Gründemann D, Schömig E. Contribution of allelic variations in transporters to the phenotype of drug response. J Psychopharmacol. 2006 Jul;20(4 Suppl):27-32. PMID: 16785267.
  33. Ksiazek P, Buraczynska K, Buraczynska M. Norepinephrine transporter gene (NET) polymorphism in patients with type 2 diabetes. Kidney Blood Press Res. 2006;29(6):338-43. PMID: 17124432.
  34. Yoshida K, Takahashi H, Higuchi H, Kamata M, Ito K, Sato K, Naito S, Shimizu T, Itoh K, Inoue K, Suzuki T, Nemeroff CB. Prediction of antidepressant response to milnacipran by norepinephrine transporter gene polymorphisms. Am J Psychiatry. 2004 Sep;161(9):1575-80. PMID: 15337646.
  35. Sand PG, Mori T, Godau C, Stöber G, Flachenecker P, Franke P, Nöthen MM, Fritze J, Maier W, Lesch KP, Riederer P, Beckmann H, Deckert J. Norepinephrine transporter gene (NET) variants in patients with panic disorder. Neurosci Lett. 2002 Nov 15;333(1):41-4. PMID: 12401556.
  36. Samochowiec J, Kucharska-Mazur J, Kaminski R, Smolka M, Rommelschpacher H, Wernicke C, Tymicz A, Schmidt LG. Norepinephrine transporter gene polymorphism is not associated with susceptibility to alcohol dependence. Psychiatry Res. 2002 Aug 30;111(2-3):229-33. PMID: 12374639.
  37. Zill P, Engel R, Baghai TC, Juckel G, Frodl T, Müller-Siecheneder F, Zwanzger P, Schüle C, Minov C, Behrens S, Rupprecht R, Hegerl U, Möller HJ, Bondy B. Identification of a naturally occurring polymorphism in the promoter region of the norepinephrine transporter and analysis in major depression. Neuropsychopharmacology. 2002 Apr;26(4):489-93. PMID: 11927173.